Organ perfusion systems
Inventors
Kay, Stuart Brian William • Robinson, David George • Canner, Philip David • Salkus, Peter Alan • Russell, Leslie James • Friend, Peter John • Coussios, Constantin C.
Assignees
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Publication Number
US-11957124-B2
Publication Date
2024-04-16
Expiration Date
Abstract
A disposable set of components for an organ perfusion system comprising a fluid supply duct for supplying fluid to the organ, a fluid removal duct for removing fluid from the organ, and a surrogate organ removably connected between the fluid supply duct and the fluid removal duct so as to form a fluid circuit, so that fluid can be circulated in the circuit in preparation for connection of the organ.
Core Innovation
The invention relates to an organ perfusion system configured for circulating perfusion fluid through an organ and for collecting excreted fluid produced by the organ. During perfusion, the system measures an excreted-fluid flow rate at each of a plurality of measurement times and stores the measurement times and the respective flow rates as flow rate information in a memory within a controller. The excreted fluid measurement system includes an excreted fluid collection volume and a sensor arranged to detect when a predetermined volume of excreted fluid has collected in the collection volume.
When the predetermined volume is reached, the controller removes the excreted fluid from the collection volume. The controller determines a plurality of times between subsequent occurrences of the predetermined volume being reached, and determines the respective flow rate of the excreted fluid from the organ from each of those time intervals. This provides flow rate information derived from repeated sensor-detected collection events during perfusion.
In additional system configurations, a perfusion fluid supply duct and a fluid removal duct are combined with a surrogate organ removably connected between the ducts so that perfusion fluid circulates in a fluid circuit during preparation for connection of the organ. The system further includes a sling for supporting the organ and a sump located below the sling for collecting leaked fluid, together with a return duct arranged to return leaked fluid from the sump to the fluid circuit. The system also includes an excreted fluid collection sump and an excreted fluid measurement system using the predetermined-volume, sensor, controller removal, and timing approach.
Claims Coverage
The document provides coverage across three independent claims, including apparatus and method claims. The common inventive features are based on detecting a predetermined excreted-fluid collection volume, removing collected excreted fluid, determining time intervals between subsequent occurrences, and storing measurement times and derived flow rate information.
Excreted fluid collection volume with sensor-detected predetermined volume cycles and controller-derived flow rate
An organ perfusion system comprising a perfusion circuit for circulating perfusion fluid through the organ, an excreted fluid collection sump, and an excreted fluid measurement system configured to measure, at each of a plurality of measurement times during perfusion, a respective flow rate of excreted fluid produced by the organ; a controller with a memory configured to store the measurement times and the respective flow rates as flow rate information; the excreted fluid measurement system includes an excreted fluid collection volume and a sensor arranged to detect when a predetermined volume of the excreted fluid has collected; the controller removes the excreted fluid in response to the predetermined volume being reached, determines a plurality of times between subsequent occurrences of the predetermined volume being reached, and determines the respective flow rate of the excreted fluid from the organ from each time interval.
Removably connected surrogate organ fluid circuit with sling, leaked-fluid sump and return duct integrated with excreted-fluid measurement
An organ perfusion system comprising a perfusion fluid supply duct for supplying perfusion fluid to the organ, a fluid removal duct for removing perfusion fluid from the organ, a surrogate organ removably connected between the perfusion fluid supply duct and the fluid removal duct to form a fluid circuit for circulating perfusion fluid in preparation for connection of the organ, a sling for supporting the organ, a sump located below the sling for collecting leaked fluid which has leaked from the organ, a return duct connected to the sump and arranged to return leaked fluid from the sump to the fluid circuit, an excreted fluid collection sump for collecting waste fluid produced by the organ, an excreted fluid measurement system configured to measure, at each of a plurality of measurement times during perfusion, a respective flow rate of the fluid excreted by the organ, and a controller with a memory storing the measurement times and respective flow rates; wherein the excreted fluid measurement system comprises an excreted fluid collection volume and a sensor arranged to detect when a predetermined volume of the excreted fluid has collected, and the controller removes the excreted fluid from the collection volume in response to the predetermined volume being reached to determine times between subsequent occurrences and determine respective flow rate from those times.
Predetermined volume detection and interval timing to determine excreted-fluid flow rate during organ perfusion
A method of perfusing an organ comprising providing a perfusion circuit, providing an excreted fluid collection volume and a sensor, connecting the organ into the perfusion circuit, circulating perfusion fluid through the perfusion circuit and the organ to perfuse the organ, collecting excreted fluid excreted by the organ, measuring for each of a plurality of times during perfusion a respective rate of excretion of the excreted fluid, and storing in memory each of the rates of excretion of the excreted fluid and the time at which it was measured as flow rate information; wherein measuring comprises detecting, using the sensor, when a predetermined volume of the excreted fluid has collected in the collection volume, removing the excreted fluid in response to the predetermined volume being reached, determining a plurality of times between subsequent occurrences of the predetermined volume being reached, and determining the respective flow rate of the excreted fluid from the organ from each time interval.
Across the independent claims, the principal claim coverage centers on excreted-fluid collection using a collection volume and sensor detection of a predetermined volume, controller removal of collected excreted fluid upon reaching the predetermined volume, determining flow rate from time intervals between subsequent predetermined-volume occurrences, and storing measurement times and derived flow rate information; one independent claim further integrates a removably connected surrogate organ fluid circuit for preparation and includes a sling with a leaked-fluid sump and return duct.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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