Blood-gas exchange device and methods of use
Inventors
Sender, Aviran • Rozentsveig, Angelina Rizansky
Assignees
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Publication Number
US-11938257-B1
Publication Date
2024-03-26
Expiration Date
Abstract
The present invention presents a novel oxygenator of the invention provides a revolutionary engineering design and management of the flow regime in a completely different way from the existing and accepted regime in the field of oxygenators, that further lower the risk levels associated with the use of oxygenators and reduces the manufacturing cost. The revolutionary technology is aimed to divert the world of blood oxygenation from the use of technology that relies on a fiber membrane or gas bubbles and causes substantial damage to the patient's blood, towards the use of technology that allows the exchange of gases without a membrane at all and is aimed to reduces risks and improves patient outcome.
Core Innovation
A blood-gas exchange device for oxygenating blood and/or removing carbon dioxide is described as a membrane-less oxygenator that uses a rotating chamber. The device channels blood to flow as a thin blood layer along walls of the rotatable chamber so that the blood directly contacts injected gases for gas exchange. The circular movement of the rotatable chamber forms and maintains the blood layer on the wall in direct contact with the gas.
The device includes a first chamber with a gas inlet and a blood inlet for inserting blood and gas, and a second chamber with a blood exit for delivering oxygenated and/or decarbonated blood and a gas exit configured to allow flow of gases out into the surrounding. A motor is configured to spin the rotatable chamber, and the rotatable chamber comprises a blood channeling element configured to direct inserted blood to flow through at least one set of opening and/or semi-openings. At least one gas opening allows flow of the inserted gas from the first chamber into the rotatable chamber toward the flowing blood, and at least one gas opening allows gas flow from the rotatable chamber to the second chamber.
Gas exchange occurs without hollow fibers by providing the blood layer directly contacting gases, with gas openings and configured gas flow paths into and out of the rotatable chamber. In some configurations, optional perforated gas columns are provided to connect gas openings and enable gas flow between the gas columns and flowing blood through bidirectional gas flow. The circular movement is described as increasing dwell time for gas exchange.
Claims Coverage
The document includes one independent claim that centers on a membrane-less blood-gas exchange device with two chambers and a motor-spun rotatable chamber that forms a blood layer directly contacting gases, enabling oxygenation and/or carbon dioxide removal. It also includes dependent claims that refine blood channeling geometry, selectable gas types, optional perforated gas columns, increased dwell time, and substitution of another body fluid for blood.
Two-chamber blood-gas exchange with rotatable chamber blood layer contact
A blood-gas exchange device comprising a first chamber with at least a gas inlet and a blood inlet, a second chamber with at least a blood exit and a gas exit, and a rotatable chamber connected to the first and second chambers, wherein the rotatable chamber comprises a blood channeling element configured to direct inserted blood to flow on the walls through at least one set of opening and/or semi-openings, at least one gas opening configured to allow flow of inserted gas into the rotatable chamber toward the flowing blood, at least one gas opening configured to allow gas flow from the rotatable chamber to the second chamber, and a motor configured to spin the rotatable chamber, wherein the circular movement channels the blood to flow along the rotatable chamber walls forming a blood layer on the wall that directly contacts with the gas and allows gas exchange for oxygenating the blood and/or removing carbon dioxide from the blood.
Multiple adjacent sets of opening and/or semi-opening blood channeling
A blood channeling element having at least two sets of adjacent openings and/or partial openings configured to direct inserted blood along the rotatable chamber walls.
Gas opening insertable with specified gas types
A gas opening configured to allow flow of inserted gas, including pure oxygen, air, oxygen-enriched air, nitrogen, carbon dioxide, or mixtures thereof.
Perforated gas columns enabling bidirectional gas flow
At least one perforated gas column configured to connect gas openings in two chambers and pass through the rotatable chamber to enable bidirectional gas flow between the perforated gas column and the flowing blood.
Circular movement increasing dwell time
The blood-gas exchange device is configured so that dwell time for gas exchange is increased by the circular movement of the rotatable chamber.
Use of another body fluid instead of blood
For the gas exchange procedure, a body fluid other than blood is inserted instead of blood.
The independent claim is directed to a two-chamber system with a motor-spun rotatable chamber that channels blood along rotatable chamber walls to form a blood layer directly contacting gas through configured blood and gas inlets/outlets and openings, enabling oxygenation and/or carbon dioxide removal. Dependent refinements specify multi-set openings/partial openings for directing blood, selectable gas types for the gas opening, optional perforated gas columns for bidirectional gas flow, increased dwell time via circular movement, and use of another body fluid instead of blood.
Stated Advantages
Oxygenates blood and/or removes carbon dioxide from the blood using membrane-less gas exchange without hollow fibers.
Allows gas exchange by forming a blood layer on rotatable chamber walls that directly contacts the gas.
Increases dwell time for gas exchange by the circular movement of the rotatable chamber.
Enables gas exchange using a body fluid other than blood instead of blood.
Documented Applications
Use as an extracorporeal life support system, including ECMO and cardiopulmonary bypass (CPB).
Use in intravascular oxygenation.
Use in implanted oxygenating devices.
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