Article coatings including oligomerized polyphenol layer and biological methods of use
Inventors
Babcock, David E. • Lundquist, Sean • Opperman, Gary • Torguson, Adriyn • Jentz, Tim
Assignees
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Publication Number
US-11938250-B2
Publication Date
2024-03-26
Expiration Date
Abstract
Embodiments of the disclosure include coatings comprising an oligomerized polyphenol layer. The oligomerized polyphenol layer can be used as an intermediate coated layer on a medical device that hydrogen bonds to a synthetic or natural polymer, which in turn can be used as a top coat or further associated with another coated layer. The multilayered coatings can provide properties such as hemocompatibility or lubricity. In other embodiments, the oligomerized polyphenol layer is used on a medical device as a hemostatic layer configured to contact blood and promote coagulation. The oligomerized polyphenol layer can also be used on the inner surface (e.g., inner diameter) of a medical device to prevent bacterial adherence. The oligomerized polyphenol layer can also be used on the surface of a in vitro diagnostic article, or a cell culture device to, promote adsorption of a biological molecule.
Core Innovation
The invention relates to a medical device comprising a water-insoluble hemostatic coating with an immobilized oligomerized polyphenol. The device is configured so that the immobilized oligomerized polyphenol comes in contact with a body fluid, and the hemostatic coating has a thickness of less than 100 nm.
The disclosed hemostatic coating is formed from oligomerized polyphenol coatings that can hydrogen-bond with natural or synthetic polymers to form multilayer coatings. The coating can include an oligomerized polyphenol layer and a second polymer layer hydrogen-bonded to the oligomerized polyphenol layer, with optional tie or intermediate layers.
The oligomerized polyphenol layer is described as hemostatic, including enhanced fibrinogen adsorption and shortened plasma clotting times. The coating also reduces bacterial adherence on medical device surfaces, including catheter inner surfaces, and improves biomolecule adsorption for in vitro assays, including improved immunoassay performance on coated microtiter plates.
Claims Coverage
The independent claims are clm-00001 and clm-00005. They center on an immobilized oligomerized polyphenol in a water-insoluble hemostatic coating context with a thickness limitation of less than 100 nm, with clm-00005 further focusing on an inner surface coating.
Water-insoluble hemostatic coating with immobilized oligomerized polyphenol
A medical device comprising a water-insoluble hemostatic coating comprising an immobilized oligomerized polyphenol, the device configured so the immobilized oligomerized polyphenol comes in contact with a body fluid.
Hemostatic coating thickness less than 100 nm
The hemostatic coating has a thickness of less than 100 nm.
Inner surface coating comprising immobilized oligomerized polyphenol layer
A medical device comprising an inner surface comprising a water-insoluble coating, the coating comprising an immobilized oligomerized polyphenol, wherein the oligomerized polyphenol is in an oligomerized polyphenol layer.
Oligomerized polyphenol layer thickness less than 100 nm
The oligomerized polyphenol layer has a thickness of less than 100 nm.
Across the independent claims, the core inventive scope is a water-insoluble coating that immobilizes an oligomerized polyphenol and enables contact with body fluid or an inner-surface configuration, while limiting the coating or layer thickness to less than 100 nm.
Stated Advantages
Improved hemocompatibility.
Improved lubricity (low friction).
Hemostasis, including enhanced fibrinogen adsorption and shortened plasma clotting times.
Reduced bacterial adherence on medical device surfaces, including catheter inner surfaces.
Improved biomolecule adsorption for in vitro assays, including improved immunoassay performance on coated microtiter plates.
Documented Applications
Medical devices with oligomerized polyphenol hemostatic coatings, including vascular implants and grafts, wound dressings and wound management devices, hemostatic barriers, occlusion articles, mesh and hernia plugs, patches, or uterine bleeding patches.
Catheter inner surfaces, to reduce bacterial adherence.
In vitro diagnostic assay articles, including improved immunoassay performance on coated microtiter plates.
Cell culture vessels, described as having oligomerized polyphenol coatings for improved biomolecule adsorption.
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