Synergistic nutritional compositions for treating cerebrovascular diseases
Inventors
PALKAR, Jotiram • Tongra, Rajendra Prasad
Assignees
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Publication Number
US-11925195-B2
Publication Date
2024-03-12
Expiration Date
Abstract
The present invention disclosed herein relates to synergistic compositions for cerebrovascular diseases. In particular, the invention relates to synergistic, efficient, composition for treating cerebral ischemia or stroke comprising specific combination of standardized celery seed extract (CSE) enriched with Dl-3-N-Butylphthalide (NBP) and SIRT1 activators, wherein D1-3-N-Butylphthalide (NBP) and SIRT1 activator are present in a weight ratio of 1:0.1 to 1:5 along with pharmaceutically acceptable excipients.
Core Innovation
The invention relates to a synergistic nutritional composition for treating ischemic stroke, comprising an exogenous combination of celery seed extract (CSE) enriched with racemic Dl-3-N-butylphthalide (NBP) and nicotinamide riboside chloride. The celery seed extract is standardized such that it comprises 90% of Dl-3-N-Butylphthalide (NBP) by weight of the celery seed extract, and nicotinamide riboside chloride is provided as a SIRT1 activator.
The composition is described as synergistic because it links NBP to the NAMPT/NAD pathway, and it links nicotinamide riboside (NR) to SIRT1 activation and downstream effects involving mTOR, autophagy, apoptosis, and infarct volume. The description connects these mechanistic pathways to increased capillary density and BDNF-mediated modulation of inflammation in the context of cerebrovascular disease and stroke.
The disclosed approach includes administering the nutritional composition for neuroprotection in cerebrovascular disease/stroke, with experimental support from an in vivo Wistar rat global ischemia-reperfusion study. In that study, the NBP plus NR combination reduced inflammatory mediators and decreased infarct damage compared with individual treatments, including reductions in TNF-α and IL-6 alongside assessment of infarct volume.
Claims Coverage
The independent claim defines one core synergistic nutritional composition for treating ischemic stroke, specifying a therapeutically active exogenous combination of two components (celery seed extract containing NBP and nicotinamide riboside chloride) together with pharmaceutically acceptable excipients. The dependent claims further refine excipient selection/quantitative ranges and an effective unit dose range for oral administration.
Synergistic nutritional composition for treating ischemic stroke
A synergistic nutritional composition effective for treating ischemic stroke, comprising 10-500 mg of a celery seed extract comprising 90% of Dl-3-N-Butylphthalide (NBP) by weight of the celery seed extract and 1-500 mg of nicotinamide riboside chloride, along with pharmaceutically acceptable excipients.
Formulation with specified excipients and weight-percent ranges
A composition wherein pharmaceutically acceptable excipients are selected from diluent, binder, lubricant, glidant, additive, surfactant, and stabilizer, each present within specified weight-percent ranges of the total composition.
Effective unit dose for oral administration
The synergistic nutritional composition is formulated so that an effective unit dose for oral administration is in the range of 50 to 500 mg.
Overall claim coverage is directed to a synergistic nutritional composition for ischemic stroke that combines standardized CSE (90% NBP in the extract) with nicotinamide riboside chloride, with additional constraints covering specific excipient categories/weight-percent ranges and an effective oral unit dose range.
Stated Advantages
Effective for treating ischemic stroke.
Neuroprotection in cerebrovascular disease/stroke is supported by reduced inflammatory mediators and decreased infarct damage in an in vivo global ischemia-reperfusion study.
Documented Applications
Treating ischemic stroke using a synergistic nutritional composition containing celery seed extract enriched with NBP and nicotinamide riboside chloride.
Neuroprotective use in cerebrovascular disease/stroke in the context of cerebral ischemia and global ischemia-reperfusion in Wistar rats.
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