Fucoidan hair growth agent
Inventors
Quan, Ying-shu • Yamashita, Hirofumi • Kamiyama, Fumio • Yamamoto, Akira • Katsumi, Hidemasa
Assignees
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Publication Number
US-11890298-B2
Publication Date
2024-02-06
Expiration Date
Abstract
To develop a novel administration method of a fucoidan-containing hair-growing agent and to provide a means for exerting excellent effects of a fucoidan.A hair-growing agent of the present invention is characterized in that it is composed of a combination of a fucoidan-containing microneedle and a fucoidan-containing liniment. A base of the fucoidan-containing microneedle is preferably a biosoluble polymer. A hair-growing method of the present invention is characterized in that the fucoidan-containing microneedle and the fucoidan-containing liniment are concomitantly used.
Core Innovation
A hair-growing agent is provided that combines a fucoidan-containing microneedle array with a fucoidan-containing liniment for administration to a skin of a subject in need thereof. Fucoidan is used in both formulations, and the administration is configured as concomitant or alternating administration to enhance delivery of fucoidan to scalp dermal layers.
The background problem addressed is that fucoidan has low oral/percutaneous uptake, which limits delivery of fucoidan to desired skin layers. To address this, the agent uses a fucoidan-containing microneedle array together with a fucoidan-containing liniment, with administration timing arranged such that fucoidan exposure is alternately provided to the skin. The disclosed approach specifies fucoidan dose and concentration ranges for the microneedle array and liniment.
The disclosed hair-growing agent further allows optional hair-growing promoters and plant extracts in addition to fucoidan, including minoxidil and various selected crude drug extract options, as well as plant extracts and tinctures such as carrot extract and ginger tincture. Experimental support is described using comparative hair growth tests, including animal testing and human/volunteer evaluation with questionnaires and hair photographs, where the combined or alternately administered fucoidan-containing microneedle array and fucoidan-containing liniment shows superior hair growth compared with microneedle alone, liniment alone, or no treatment.
Claims Coverage
The independent claim provides a hair-growing method using alternating administration of two fucoidan-containing formulations with specified fucoidan dose and concentration ranges, and it covers the core inventive concept of combining and alternating a fucoidan-containing microneedle array with a fucoidan-containing liniment.
Alternately administering fucoidan-containing microneedle array and fucoidan-containing liniment
A hair-growing method comprising alternately administering one or more doses of a fucoidan-containing microneedle array and one or more doses of a fucoidan-containing liniment to a skin of a subject in need thereof.
Fucoidan dose range in the microneedle array
The fucoidan in the fucoidan-containing microneedle array is present at a dose of 0.1 μg to 2 mg per one fucoidan-containing microneedle array.
Fucoidan concentration range in the liniment
The fucoidan in the fucoidan-containing liniment is present at a concentration of 0.1 μg/mL to 100 mg/mL.
Overall claim coverage centers on alternately administering fucoidan in a fucoidan-containing microneedle array and a fucoidan-containing liniment, while maintaining the specified fucoidan dose and concentration ranges for those two formulations.
Stated Advantages
Enhanced delivery of fucoidan to scalp dermal layers.
Superior hair growth compared with microneedle alone, liniment alone, or no treatment.
High user-perceived satisfaction.
Minimal adverse effects.
Documented Applications
Hair-growing treatment for a skin of a subject in need thereof, including evaluation using animal testing and human/volunteer questionnaires with hair photographs.
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