Cartridge and system for analyzing body liquid
Inventors
Salomon, Noga • Oved, Kfir • Khalfin, Yana • Katzenelson, Omer Nahum • GELMAN, Amir • BROUK RUDICH, Moran • NAVON, Roy • COHEN-DOTAN, Assaf • Eden, Eran • Tzaban, Salit • Zangvil, Arnon • Halbreich, Ofer • Fenwick, Matthew • Scott-Murphy, Adrian Charles Ian • Yeung, Matthew Hou-Pou • LUTHER, James William • Tornaghi, Barbara • BESANA, Andrea • CRUGNALE, Thomas Sanelli
Assignees
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Publication Number
US-11883825-B2
Publication Date
2024-01-30
Expiration Date
Abstract
In a cartridge device for analyzing a body liquid, a first member of the cartridge has two or more wells for performing assays, and a second member of the cartridge has a compartment for holding one or more disposable pipette tips.
Core Innovation
A cartridge device for analyzing a body liquid includes at least one disposable pipette tip. The cartridge has a first member with a plurality of wells configured for performing assays, and a second member connected to the first member has a compartment holding the at least one disposable pipette tip.
The second member is hingedly connected to the first member such that, when the first member and the second member are held horizontally, the pipette tip is also horizontal. When the hingedly connected second member is rotated downwards relative to the horizontally held first member, the compartment holds the at least one disposable pipette tip in a vertical orientation.
The cartridge architecture also includes wells configured for antibody-based immunological assays using antibody pairs, including an immobilized antibody on a solid magnetic carrier and a labeled antibody, with target substances in the body liquid. The cartridge architecture further includes features for well sealing and fluid handling, including waste collection and optional moisture absorption.
Claims Coverage
The independent claim covers a hingedly connected cartridge architecture that provides a controlled change in pipette-tip orientation between horizontal and vertical positions while moving from a horizontally held to a rotated-down configuration. Across the independent-claim family, the inventive features are further specialized with well coverings and waste chamber coverage, partitioned pipette-tip compartments, and antibody/magnetic-carrier assay chemistry.
Hinged pipette-tip orientation control
A second member hingedly connected to a first member so that when the first member and second member are held horizontally the at least one disposable pipette tip is also horizontal, and when the hingedly connected second member is rotated downwards relative to the horizontally held first member, the compartment holds the at least one disposable pipette tip in a vertical orientation.
Assay wells with antibody-based magnetic separation format
A first antibody immobilized in a well on a solid magnetic carrier and a second labeled antibody in another well, wherein the antibodies are chosen to specifically bind a target substance in body liquid.
Partitioned tip-holding compartment
The second member is divided into a plurality of partitions, with each partition configured to hold a single pipette tip.
Openable or pierceable well covering
An openable or pierceable covering structure that covers the plurality of wells.
Waste collecting chamber lid exposed by rotation
A lid covers a waste collecting chamber and is connected to or extends from the second member so the lid becomes exposed when the horizontally held second member is rotated downward from a horizontal orientation to a vertical orientation relative to the first member.
Disposable pipette tip with immobilized antibody on solid magnetic carriers
A disposable pipette tip includes an immobilized antibody attached to solid magnetic carriers.
Overall, the claim coverage centers on a hinged cartridge mechanism that switches a disposable pipette tip between horizontal and vertical orientations, and it further narrows the cartridge by adding well covering structures, a waste chamber lid linked to the hinge motion, a partitioned tip compartment, and antibody-based assay structures including magnetic carriers and labeled antibodies.
Stated Advantages
Documented Applications
Not explicitly described in patent.
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