IOL with drug delivery devices and uninterrupted PCO barrier edge
Inventors
Cable, II, Craig Alan • Sussman, Glenn R. • Dennewill, James R. • Kahook, Malik Y.
Assignees
University of Colorado Colorado Springs • Spyglass Pharma Inc
Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-11883277-B2
Publication Date
2024-01-30
Expiration Date
Abstract
An ophthalmic implant including an IOL with haptics, and drug delivery devices secured to the haptics. The posterior-most extent of the drug delivery device is located anterior to the posterior edge or PCE barrier edge, of the IOL. In other configurations, the drug delivery devices are provided with PCO barrier edges.
Core Innovation
The invention relates to ophthalmic implants that combine an intraocular lens (IOL) with drug-delivery devices mounted with the IOL haptics. The described structure preserves an uninterrupted posterior capsular opacification (PCO) barrier edge, including a sharply angular or square edge, while enabling drug delivery from the implant.
In the implant, the drug-delivery device includes a posterior panel and an anterior panel joined by a pair of posts, with an aperture bounded by the posterior panel, the anterior panel, and the posts. The IOL haptic is received within the aperture so that at least a portion of the posterior panel side wall lies adjacent the circumferential side wall of the IOL, while at least a portion of the anterior panel side wall protrudes inward on the anterior side of the IOL.
The disclosed arrangements further define spatial relationships using planes, including an offset plane for drug-device posterior-most surfaces relative to the IOL PCO barrier edge plane, so that capsule fusion to the sharp edge is not disrupted. Alternative embodiments allow drug-device PCO barrier edges to be distinct from or coplanar with the IOL’s, and additional structural configurations are described for stable positioning and anti-rotation or anti-migration, including keyed aperture to haptic base, detent ridge and groove, notch-interference fit, shoulder interference fit, and limiting tilt or twist using an anterior panel with an edge in a plane parallel to the IOL and the capsular bag equator.
Claims Coverage
The document includes three independent claims (clm-00001, clm-00011, clm-00019). Across them, the coverage focuses on an IOL combined with a drug-delivery device where the IOL haptic is received in an aperture and panel side walls are positioned to preserve the IOL circumferential PCO barrier edge relationship while providing inward protrusion of the anterior panel side wall.
Haptic-received drug-delivery device with posterior adjacency and anterior protrusion
An ophthalmic implant comprising an IOL with a haptic extending outward from a circumferential side wall, and a drug delivery device with a posterior panel and an anterior panel joined by posts and defining an aperture, wherein the haptic is received within the aperture such that at least a portion of the posterior panel side wall lies adjacent the circumferential side wall of the IOL and at least a portion of the anterior panel side wall protrudes inward of the circumferential side wall on the anterior side of the IOL.
Anterior panel attachment structure aperture receiving the haptic to create inward anterior protrusion
An ophthalmic implant comprising an IOL with a haptic coupled to and extending outwards from a circumferential side wall, and a drug delivery device with an anterior panel and an attachment structure extending posteriorly from the anterior panel, wherein the attachment structure defines an aperture extending therethrough, and the haptic is received within the aperture such that at least a portion of the anterior panel side wall protrudes inward of the circumferential side wall of the IOL on the anterior side of the IOL.
Posterior and anterior structures with aperture receiving the haptic while preserving posterior adjacency and anterior protrusion
An ophthalmic implant comprising an IOL with a haptic extending outwards from a circumferential side wall, and a drug delivery device with a posterior structure and an anterior structure joined by a pair of posts and defining an aperture, wherein the haptic is received within the aperture such that at least a portion of the posterior structure side wall lies adjacent the circumferential side wall of the IOL and at least a portion of the anterior structure side wall protrudes inward of the circumferential side wall on the anterior side of the IOL.
Overall, the claim set covers ophthalmic implants combining an IOL and a drug-delivery device in which an aperture receives the IOL haptic and positions posterior and anterior panel or structure side walls relative to the IOL circumferential side wall, including inward protrusion of an anterior panel or structure on the anterior side.
Stated Advantages
Preserves an uninterrupted posterior capsular opacification (PCO) barrier edge while enabling drug delivery.
Offsets drug-delivery posterior-most surfaces relative to an IOL PCO barrier edge plane to avoid disrupting capsule fusion to the sharp edge.
Provides stable positioning and anti-rotation or anti-migration via keyed aperture and interference features.
Limits tilt or twist using an anterior panel with an edge in a plane parallel to the IOL and capsular bag equator.
Documented Applications
Glaucoma treatment using the described ophthalmic implant drug delivery.
Macular degeneration treatment using the described ophthalmic implant drug delivery.
Uveitis treatment using the described ophthalmic implant drug delivery.
PCO reduction using the described ophthalmic implant drug delivery.
Management of post-operative inflammation or infection using the described ophthalmic implant drug delivery.
Use with other capsular bag implants, including capsular tension rings or scaffolds.
Interested in licensing this patent?