Heater integrated gas chromatography column device
Inventors
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Assignees
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BioneerBioneer is a biotechnology company specializing in molecular biology, offering solutions in nucleic acid synthesis, molecular diagnostics, protein production, and laboratory automation. The company's expertise covers oligonucleotide chemistry, gene synthesis, sample preparation, molecular diagnostics, and analytical services such as mass spectrometry and sequencing, serving clinical, research, and industrial sectors globally.
Bioneer is a biotechnology company specializing in molecular biology, offering solutions in nucleic acid synthesis, molecular diagnostics, protein production, and laboratory automation. The company's expertise covers oligonucleotide chemistry, gene synthesis, sample preparation, molecular diagnostics, and analytical services such as mass spectrometry and sequencing, serving clinical, research, and industrial sectors globally.
Publication Number
US-11879876-B2
Publication Date
2024-01-23
Expiration Date
Abstract
A heater integrated gas chromatography (GC) column device according to the present invention is capable of precisely and uniformly controlling a temperature by having a high thermal conductivity, and raising and lowering a temperature at a high speed by having a low thermal mass, such that a measuring time is significantly decreased. The GC column is in contact with a bobbin with a homogeneous temperature distribution, and thus a temperature is homogeneously distributed in each GC column. Further, the heater integrated GC column device according to the present invention has the above-described effects and may have a smaller size.
Core Innovation
The invention is a heater integrated gas chromatography (GC) column device in which a GC column is wound around a metal bobbin that has high thermal conductivity. The GC column is wound while being adjacent to an outer surface of the bobbin, so the bobbin serves as a thermal control element for the GC column.
The bobbin includes an insulating layer formed as a metal oxide film on an inner surface of the bobbin. A heat generating layer is bonded to the insulating layer and includes selected carbon nanotubes and/or a carbon nanotube-metal composite, and a metal electrode is formed to be in contact with the heat generating layer.
Thermal control is achieved with low thermal mass and fast ramping to provide precise and uniformly controlled temperature, including thermal homogeneity and improved resolution. Optional temperature sensor devices and a noble metal layer on the metal electrode are included to support temperature measurement, and the device architecture supports homogeneous temperature distribution by winding the GC column adjacent to the bobbin outer surface.
Claims Coverage
The independent claim defines one heater integrated GC column device architecture with a metal, high-thermal-conductivity bobbin and a bonded carbon-nanotube-based heat generating layer separated from the bobbin by a metal-oxide insulating layer. It includes a metal electrode contacting the heat generating layer and a GC column wound adjacent to the bobbin outer surface. Dependent claims further refine material choices and structural configurations, and add optional temperature sensing and noble-metal coverage.
High thermal conductivity metal bobbin with GC column adjacency
A bobbin formed of a metal having a high thermal conductivity, and a GC column wound around the bobbin while being adjacent to an outer surface of the bobbin.
Metal oxide insulating layer on inner surface
An insulating layer including a metal oxide film formed on an inner surface of the bobbin.
Bonded carbon nanotube heat generating layer
A heat generating layer bonded to the insulating layer and including any one or more selected from the group consisting of carbon nanotubes and a carbon nanotube-metal composite.
Metal electrode in contact with heat generating layer
A metal electrode formed to be in contact with the heat generating layer.
Overall claim coverage centers on a heater integrated GC column device that thermally drives a GC column using a high-thermal-conductivity metal bobbin, with a metal-oxide insulating layer and a bonded carbon nanotube (or carbon nanotube-metal composite) heat generating layer contacted by a metal electrode.
Stated Advantages
Precise and uniformly controlled temperature.
Improved resolution.
Fast temperature ramping with reduced measurement and stabilization time (reduced thermal measurement/stabilization time).
Thermal homogeneity and homogeneous temperature distribution.
Documented Applications
Used as a heater integrated gas chromatography (GC) column device for temperature-controlled GC operation.
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