Dermal patch for collecting a physiological sample
Inventors
Nawana, Namal • Al-Shamsie, Ziad Tarik
Assignees
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Publication Number
US-11877848-B2
Publication Date
2024-01-23
Expiration Date
Abstract
A dermal patch for collecting a physiological sample includes a housing with a collection chamber, a sample channel and a pin within a receptacle of the housing. The sample channel is configured to direct a physiological sample drawn from a subject to the collection chamber. The pin is removably positioned within the receptacle and is configured to move from an undeployed position to a deployed position. The pin is configured to seal the receptacle when in the undeployed position and is further configured to facilitate generation of negative pressure in the sample channel when the pin is moved from the undeployed to the deployed position.
Core Innovation
The invention describes a dermal patch configured to attach to a subject’s skin for physiological sample collection. The housing includes an opening that provides access to the subject’s skin when the dermal patch is attached, and a lancet is configured to engage with the opening and includes a needle movable from an undeployed position to a deployed position to puncture the skin and draw a physiological sample into the dermal patch system.
The system further includes a sample capture arrangement that uses a movable pin to generate a vacuum within the housing. The vacuum generated by the pin is proportional to the movement of the pin, and the pin is disposed within a receptacle where the pin is configured to seal the receptacle; this vacuum function is used to drive the collected physiological sample into a collection chamber.
In addition, the invention describes optional processing fluid delivery and analyte detection within the same dermal patch. A processing-fluid reservoir is formed of a frangible membrane and is coupled to the housing, and a slider compresses the fluid pouch into a puncture element to rupture the fluid pouch and release processing fluid into a processing channel for mixing with the drawn physiological sample.
Claims Coverage
The independent claims are clm-00001 and clm-00002. They share the skin-attached dermal patch with an opening and a lancet that punctures skin to draw a physiological sample, and they differ in the sample capture/driver mechanism. Across the independent claims, the coverage emphasizes three inventive features: a frangible fluid pouch processing system ruptured by a slider into a puncture element, a vacuum-generating sealed receptacle with proportional vacuum, and a skin access opening with lancet puncture.
Skin-attached dermal patch with skin access opening and lancet puncture
A dermal patch comprising a housing configured to attach to a subject’s skin; the housing includes an opening to provide access to the subject’s skin when the dermal patch is attached; and a lancet configured to engage with the opening, wherein the lancet includes a needle movable from an undeployed position to a deployed position to puncture the skin and draw a physiological sample.
Frangible processing fluid pouch ruptured by slider into puncture element
A fluid pouch coupled to the housing, wherein the fluid pouch is configured to store a processing fluid and is formed of a frangible membrane; and a slider coupled to the housing, wherein the housing further includes a puncture element, and wherein the slider is configured to compress the fluid pouch into the puncture element to rupture the fluid pouch.
Moveable sealed pin generating proportional vacuum within housing
A moveable pin disposed within the housing, wherein the pin is configured to generate a vacuum within the housing when moved, and wherein the vacuum generated by the pin is proportional to the movement of the pin; and a receptacle, wherein the pin is disposed within the receptacle, and wherein the pin is configured to seal the receptacle.
The claim set covers a skin-attached dermal patch system that punctures skin with a lancet to draw physiological sample, combined either with a frangible processing fluid pouch ruptured by a slider into a puncture element or with a moveable sealed pin that generates vacuum proportional to pin movement to drive sample capture.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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