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Publication Number
US-11872111-B2
Publication Date
2024-01-16
Expiration Date
Abstract
The present invention relates to a device and a method. The device of the present invention comprising a patch comprising: a substrate, and an adhesive on the substrate. Further, the patch is configured to be attached to a skin via the adhesive to form a pocket between the patch and the skin, to allow introduction of a material into the pocket, and to hold the material within the pocket.
Core Innovation
The invention provides an adhesive skin patch device that includes a substrate and an adhesive configured to attach to skin to form a pocket between the patch and the skin, wherein the adhesive circumscribes the pocket. The pocket is prefilled with a first material and a second material, and an opening in the substrate is provided with a flap that covers the opening. The flap is different than the substrate and is configured for the introduction of materials in the patch.
The first material is configured to activate under a specific condition by reacting the first material with the second material, and the device allows introduction of the second material into the pocket through the opening. The device is configured to hold the first material and the second material within the pocket, maintaining them in the pocket after attachment to the skin. This pocket-and-opening arrangement supports localization of the materials at the skin interface.
The patch is further configured to image a portion of the skin on which the patch is placed. In the pocket, the first material includes a combination of penetration enhancer and dye, and the patch enables localized imaging based on the activation of the first material by reaction with the introduced second material under a specific condition. The disclosed options include pocket contents that can include dyes and tags, as well as particle- or radionuclide-related materials, and imaging modalities including radiography, MRI, nuclear medicine, ultrasound, PET, and optical or fluorescent imaging.
Claims Coverage
The document provides one independent claim. The claim centers on an adhesive skin patch that forms a pocket prefilled with a first material and a second material introduced through an opening under a flap, with the first material activating by reacting with the second material under a specific condition, and the patch imaging a portion of the skin.
Adhesive skin patch forming a pocket
A patch configured to attach to skin via the adhesive to form the pocket between the patch and the skin, wherein the adhesive circumscribes the pocket.
Prefilled first material including penetration enhancer and dye
A pocket under the substrate prefilled with a first material and a second material, wherein the first material is a combination of penetration enhancer and dye.
Opening in substrate with flap for material introduction
An opening in the substrate and a flap, wherein the flap covers the opening and is different than the substrate, and is configured for the introduction of materials in the patch.
Second material introduction and pocket retention
The patch is configured to allow introduction of a second material into the pocket through the opening, and hold the first material and the second material within the pocket.
First material activation by reaction with second material under specific condition
The first material is configured to activate under a specific condition by reacting the first material with the second material.
Skin imaging based on the patch
The device is configured to image a portion of the skin on which the patch is placed.
Across the independent claim, the inventive concept combines an adhesive patch that forms and retains a pocket at the skin interface, a substrate opening covered by a flap for introducing a second material, and a prefilled first material that activates under a specific condition by reacting with the second material, enabling imaging of the skin portion.
Stated Advantages
Enables imaging of a portion of the skin on which the patch is placed.
Allows introduction of a second material into a pocket formed between the patch and skin without breaching the skin.
Provides localized retention of first and second materials within the pocket after attachment to skin.
Documented Applications
Localized imaging of a portion of skin using the patch configured to image the portion after activation of the first material by reacting with the second material under a specific condition.
Support localized drug use and localized interaction promoted by activation conditions such as radiation or heat, including activation of pocket material and reaction or mixing with a second material [procedural detail omitted for safety].
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