Systems and methods for minimally invasive drug delivery to a subarachnoid space

Inventors

Malek, Adel M. • Heilman, Carl B. • Rezac, David A. • Sattell, Jack B. • Bonin, Alexander

Assignees

Cerevasc Inc

Abstract

Endovascular drug delivery systems and methods are disclosed herein for delivering a therapeutic agent to the intracranial subarachnoid space of a patient, and/or deploying an endovascular drug delivery device distal portion in the intracranial subarachnoid space and a portion of the drug delivery device body in a dural venous sinus such that a therapeutic agent is delivered from the deployed drug delivery device into the intracranial subarachnoid space.

Core Innovation

The invention provides methods for accessing an intracranial subarachnoid space (ISAS) through a blood vessel wall by using a 3D volumetric reconstruction of the vessel wall. A target location in the 3D reconstruction is identified for accessing the ISAS with a delivery catheter, and a portion of the 3D reconstruction including the target location is overlaid on a fluoroscopy imaging display of the patient’s anatomy including the vessel wall. The overlaid portion is used to visually track movement of the delivery catheter within the vessel to the target location.

After visual tracking to the target location, the method penetrates the vessel wall to create an anastomosis between the vessel and the ISAS. The method then accesses the ISAS through the anastomosis with the delivery catheter. In this access state, the method administers a therapeutic agent from the delivery catheter into the ISAS, or deploys a drug delivery device in the anastomosis via the delivery catheter.

In further embodiments, the invention includes navigating the delivery catheter within the vessel to the target location, and the 3D volumetric reconstruction of the vessel wall may be acquired using 3D-rotational venography or angiography. Additional embodiments overlay MR imaging data set of the patient’s anatomy, including the vessel wall, onto corresponding portions of the 3D reconstruction and a fluoroscopy imaging display.

Claims Coverage

The independent claims cover seven core aspects: creating an anastomosis by penetrating the vessel wall at a target location, using 3D volumetric vessel-wall reconstruction with fluoroscopy overlay for visual catheter tracking or navigation, accessing the ISAS through the anastomosis, administering a therapeutic agent, deploying a drug delivery device, acquiring the 3D reconstruction using 3D-rotational venography or angiography, and overlaying MR imaging data onto the 3D reconstruction and fluoroscopy display.

Across the independent claims, the inventive coverage centers on targeting an access site using a 3D volumetric vessel-wall reconstruction with fluoroscopy imaging overlay to visually track the delivery catheter, penetrating the vessel wall to create an anastomosis, and then accessing the ISAS through the anastomosis. The claims further distinguish between administering a therapeutic agent and deploying a drug delivery device via the delivery catheter, with additional independent coverage specifying navigating to the target location and defining modalities for obtaining the 3D reconstruction and overlaying MR imaging data.

Stated Advantages

Documented Applications

No documented applications found