Method for testing suitability of microneedle material suitable for manufacture employing elongation process, and microneedle manufacturing method comprising same
Inventors
Jin, Ju Young • LEE, Moon Su • Kim, Tae Hyung • Kim, Jung Dong • Jeong, Do Hyeon
Assignees
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Publication Number
US-11850388-B2
Publication Date
2023-12-26
Expiration Date
Abstract
A method of manufacturing a microneedle includes selecting and providing a microneedle material whose viscosity/elastic modulus measured for each shear rate using a viscoelasticity measuring equipment falls in a range between a predetermined upper limit and a predetermined lower limit, and manufacturing the microneedle using the microneedle material by an extension process.
Core Innovation
The disclosure concerns selecting and providing a microneedle material for an extension process by measuring a viscosity/elastic modulus for each shear rate using viscoelasticity measuring equipment. For the selected material, the viscosity/elastic modulus measured for each shear rate falls in a range between a predetermined upper limit and a predetermined lower limit, and suitability is defined by whether measured values comply with predetermined upper and lower limits across shear rate conditions.
In some embodiments, the viscosity/elastic modulus measured for each shear rate continuously decreases as the shear rate increases. The selection criterion is therefore based on whether all values lie between the predetermined upper limit and the predetermined lower limit, and, when applicable, whether the values continuously decrease with increasing shear rate. The selected and provided microneedle material is then used to manufacture the microneedle using an extension process.
The disclosure further includes a testing method for determining microneedle material suitability by measuring viscosity/elastic modulus for each shear rate using viscoelasticity measuring equipment. The measured values are checked to determine whether all values fall in a range between a predetermined upper limit and a predetermined lower limit, and, when applicable, whether the values continuously decrease as the shear rate increases. When the values are determined to fall within the range, the microneedle material is determined suitable for forming a microneedle by an extension process.
Claims Coverage
The partial content includes four independent claims: clm-00001, clm-00002, clm-00004, and clm-00005. Each claim centers on microneedle manufacturing or microneedle material suitability testing using viscosity/elastic modulus measured for each shear rate with viscoelasticity measuring equipment, constrained by predetermined upper and lower limits, optionally including a continuous decrease requirement.
Selecting a microneedle material within predetermined viscosity/elastic modulus bounds per shear rate and manufacturing by extension
Selecting and providing a microneedle material whose viscosity/elastic modulus measured for each shear rate using viscoelasticity measuring equipment falls in a range between a predetermined upper limit and a predetermined lower limit, and manufacturing the microneedle using the selected and provided microneedle material by an extension process.
Continuously decreasing viscosity/elastic modulus with shear rate while manufacturing by extension
Selecting and providing a microneedle material whose viscosity/elastic modulus measured for each shear rate using a viscoelasticity measuring equipment falls in a range between a predetermined upper limit and a predetermined lower limit, wherein the viscosity/elastic modulus measured for each shear rate continuously decreases as the shear rate increases, and manufacturing the microneedle using the microneedle material by an extension process.
Testing microneedle material suitability by checking viscosity/elastic modulus within upper/lower ranges per shear rate
Measuring a viscosity/elastic modulus of the microneedle material for each shear rate using a viscoelasticity measuring equipment, checking whether all values of the viscosity/elastic modulus measured for each shear rate fall in a range between a predetermined upper limit and a predetermined lower limit, and when all values fall in the range, determining that the microneedle material is suitable for forming a microneedle by an extension process.
Testing microneedle material suitability by range compliance and continuous decrease of viscosity/elastic modulus with shear rate
Measuring a viscosity/elastic modulus of the microneedle material for each shear rate using a viscoelasticity measuring equipment, checking whether all values of the viscosity/elastic modulus measured for each shear rate fall in a range between a predetermined upper limit and a predetermined lower limit, determining whether all values continuously decrease as the shear rate increases, and when all values are determined to continuously decrease as the shear rate increases, determining that the microneedle material is suitable for forming a microneedle by an extension process.
Across the independent claims, microneedle material suitability and microneedle manufacturing by an extension process are governed by viscosity/elastic modulus measured for each shear rate using viscoelasticity measuring equipment, constrained by predetermined upper and lower limits, with optional requirement that the viscosity/elastic modulus continuously decreases as shear rate increases.
Stated Advantages
Documented Applications
No documented applications found
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