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Publication Number
US-11844933-B2
Publication Date
2023-12-19
Expiration Date
Abstract
An auto-injector operable in a single activation step. The auto-injector is automatically armed when removed from its carrying receptacle. The auto-injector may be prefilled with more than one constituent of a beneficial agent, stored in separated compartments, in such an arrangement that the compartments will automatically merge when the auto-injector is removed from its carrying receptacle.
Core Innovation
The auto-injector device is configured for single activation to deliver parenteral doses of two separated beneficial agent doses to tissue of a subject. The auto-injector body includes a first container and a second container, each housed in the auto-injector body, with respective pierceable regions and respective needles configured to pierce the pierceable regions and deliver the corresponding beneficial agent dose when the device is activated.
Upon activation, the first needle and the second needle are deployed from the auto-injector device to inject the first beneficial agent through the first needle and the second beneficial agent through the second needle. The device transitions between a first auto-injector device arrangement state and a second auto-injector device arrangement state, in which the beneficial agents are not in fluid communication with the corresponding pierceable regions in the first arrangement state and are in fluid communication with the corresponding pierceable regions in the second arrangement state.
The device also includes automatic arming and state-dependent safety that prevents expelling in a safe/pre-use state and enables expelling in an armed state, including automatic arming when the auto-injector is removed from a carrying receptacle. Prefilled beneficial-agent constituents are stored in separated compartments and automatically merged/mixed when the auto-injector is removed from the receptacle, with additional embodiments describing arming arrangements, needle deployment, timing control via pressure thresholds and bleeding passageways/valves, and abrupt needle retraction for tactile confirmation.
Claims Coverage
Two independent claims are identified, each sharing a core inventive structure of an auto-injector that delivers two separated beneficial agent doses upon a single activation with deployment of first and second needles, while one claim additionally adds an arrangement-state fluid communication transition mechanism and state-dependent enabling.
Two needle deployment for two separated beneficial agent doses upon single activation
The auto-injector body is configured such that when the auto-injector device is activated, the first needle and the second needle are deployed from the auto-injector device to inject the first beneficial agent through the first needle and the second beneficial agent through the second needle.
Arrangement-state transition enabling fluid communication with pierceable regions
In a first auto-injector device arrangement state, the first beneficial agent is not in fluid communication with the first pierceable region and the second beneficial agent is not in fluid communication with the second pierceable region; the device transitions to a second auto-injector device arrangement state in which the first beneficial agent is in fluid communication with the first pierceable region and the second beneficial agent is in fluid communication with the second pierceable region.
Overall, the claim coverage centers on an auto-injector for parenteral delivery of two separated beneficial agent doses using two needles deployed upon a single activation, with one claim additionally requiring a first and second auto-injector device arrangement state that controls fluid communication between each beneficial agent and its pierceable region.
Stated Advantages
Automatic arming when the auto-injector is removed from a carrying receptacle.
State-dependent safety that prevents expelling in a safe/pre-use configuration and enables expelling in an armed state.
Reduced user error via ornamental tactile/visual recognition features and use indication windows.
Tactile confirmation via abrupt needle retraction.
Simultaneous delivery using two administration devices/needles.
Documented Applications
Parenteral delivery of two separated beneficial agent doses to a tissue of a subject upon a single activation.
Simultaneous injections using two administration devices/needles.
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