Neuromodulation system
Inventors
SCHELTIENNE, Mathieu • Paoles, Edoardo • Tol, Jeroen • Bakker, Jurriaan
Assignees
IT'IS FOUNDATION • Ecole Polytechnique Federale de Lausanne EPFL • Onward Medical NV
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Publication Number
US-11839766-B2
Publication Date
2023-12-12
Expiration Date
Abstract
A neuromodulation system comprising: at least one input means for inputting patient data into the neuromodulation system;at least one model calculation and building means for building a patient model, the patient model describing the anatomy and/or physiology and/or pathophysiology and the real and/or simulated reaction of the patient on a provided and/or simulated neuromodulation;at least one computation means for using the patient model (M) and calculating the impact of the provided and/or simulated neuromodulation. The present invention further relates to a method for providing neuromodulation.
Core Innovation
The invention relates to a neuromodulation system for inputting patient data, building a patient model, and computing an impact of neuromodulation for a patient. The patient model comprises three-dimensional reconstructions of dorsal roots of the patient, coupled with electrophysiology models of multiple types of nerve fibers included in the three-dimensional reconstructions of the dorsal roots.
The system determines a neuromodulation impact by calculating a difference between a target and a simulated percentage activation of nerve fibers. The difference is determined for multiple combinations of dorsal root and nerve fiber type using the three-dimensional reconstructions and the coupled electrophysiology models.
In additional implementations, the system outputs planning data across pre-operative, intra-operative, and post-operative planning. The system may acquire intra-operative planning data comprising intra-operative imaging data acquired using specified imaging and monitoring modalities, and includes computing or model calculation modules coupled to an implantable pulse generator or a spinal implant with multiple electrodes.
Claims Coverage
The document contains two independent claims, a neuromodulation system claim and a method claim. Both claims share the core inventive framework of patient-data input, a patient model with 3D dorsal-root reconstructions coupled to electrophysiology models, and impact calculation by comparing target and simulated percentage activation across dorsal-root and nerve-fiber combinations.
Patient-data input for neuromodulation modeling
The neuromodulation system comprises at least one input module for inputting patient data into the neuromodulation system.
Patient model with 3D dorsal-root reconstructions coupled to electrophysiology models
The system comprises at least one model calculation and building module for building a patient model, the patient model comprising three-dimensional reconstructions of dorsal roots of the patient, the three-dimensional reconstructions coupled with electrophysiology models of multiple types of nerve fibers included in the three-dimensional reconstructions of the dorsal roots.
Impact calculation as target-minus-simulated percentage activation over dorsal root and nerve-fiber combinations
The system comprises at least one computation module for calculating an impact of neuromodulation by determining a difference between a target and a simulated percentage activation of nerve fibers for multiple combinations of dorsal root and nerve fiber type using the three-dimensional reconstructions and the coupled electrophysiology models.
Method for providing neuromodulation using patient model and target-minus-simulated activation
A method for providing neuromodulation comprising inputting patient data of a patient, building a patient model comprising three-dimensional reconstructions of dorsal roots of the patient coupled with electrophysiology models of multiple types of nerve fibers, and calculating an impact of neuromodulation by determining a difference between a target and a simulated percentage activation of nerve fibers for multiple combinations of dorsal root and nerve fiber type.
Across both independent claims, the shared inventive theme is simulation-based neuromodulation impact calculation driven by a patient-specific model with 3D dorsal-root reconstructions coupled to electrophysiology models, followed by computing a target-versus-simulated percentage activation difference across multiple dorsal root and nerve fiber type combinations.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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