Antimicrobial, disinfecting, and wound healing compositions and methods for producing and using the same
Inventors
Assignees
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Publication Number
US-11839213-B2
Publication Date
2023-12-12
Expiration Date
Abstract
The present invention relates to antimicrobial, disinfecting, and wound healing compositions and methods for producing and using the same. The compositions may comprise one or more of a peracid, a hydroperoxide, a bis(hydroperoxide), or an epoxide.
Core Innovation
The invention describes antimicrobial/disinfecting and wound-healing compositions and production/use methods based on combinations of peracids/peroxyacids, hydroperoxides, and epoxides. In particular, the wound-healing composition includes a therapeutically effective amount of acetoacetic acid, or a salt of acetoacetic acid, together with a hydroperoxide component. The compositions are described as stable aqueous compositions that can reduce microbes and support wound healing.
The background problem addressed is the need for compositions and methods capable of reducing microbes, including vegetative bacteria and spores, and for treating infected wounds. The disclosure emphasizes antimicrobial/disinfecting efficacy across multiple microorganisms and provides that the compositions can reduce microbes/disease on substrates. The document further characterizes the compositions in terms of keto-acid/peracid species relationships and synergetic roles of keto-acid/peracid species.
The disclosure includes specific wound-healing composition examples using acetoacetic acid salts in combination with hydroperoxides, and compositions where keto acids generate peroxy/hydroperoxy/epoxide species. The document also includes examples and tracking of pyruvic acid plus hydrogen peroxide products over extended time, along with synthesis confirmation using mass spectrometry and chemical reaction schemes. Supporting data include kill-time efficacy and comparative activity against other peracid systems, and microbial effectiveness tables with reported log-reduction outcomes.
Claims Coverage
The provided independent claim set contains 1 independent claim (covering wound healing), with dependent claims that define specific formulation members and additional peroxide/acid components. Overall, the inventive coverage is centered on acetoacetic acid (or salt) plus a hydroperoxide for contacting a wound in a subject, with refinements that broaden the specification of the acid and peroxide system.
Wound healing with acetoacetic acid (or salt) and hydroperoxide
A method for healing a wound in a subject comprising contacting the wound with a therapeutically effective amount of a composition comprising acetoacetic acid, or a salt of acetoacetic acid, wherein the composition further comprises a hydroperoxide.
Acetoacetic acid salt selection for the wound-healing composition
The method of claim 1 in which the acetoacetic acid salt is selected from lithium, sodium, potassium, rubidium, cesium, magnesium, or calcium salts.
Addition of a keto acid component
The method of claim 1 in which the composition further comprises a keto acid.
Use of specific keto acids (pyruvic/parapyruvic/citramalic)
The method of claim 1 in which the composition further includes pyruvic acid, parapyruvic acid, or citramalic acid (or any salts thereof, or mixtures).
Addition of hydrogen peroxide
The method of claim 1 in which the composition further includes hydrogen peroxide.
Addition of an acetoacetate ester
The method of claim 1 in which the composition further includes an acetoacetate ester.
Across the claim set, the core inventive approach is contacting a wound with a therapeutically effective acetoacetic acid (or acetoacetic acid salt) composition that includes a hydroperoxide, optionally further specifying acetoacetic acid salt cations, adding a keto acid (including pyruvic/parapyruvic/citramalic), and/or adding hydrogen peroxide and an acetoacetate ester.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Treating infected wounds by healing a wound in a subject by contacting the wound with a composition comprising acetoacetic acid (or salt) and a hydroperoxide.
Reducing microbes for antimicrobial/disinfecting purposes, including kill-time efficacy against C. difficile and reported log-reduction outcomes in microbial effectiveness tests.
Disinfecting/disease reduction on substrates (described as reducing microbes/disease on substrates).
Reducing microbes including spores, as described by effectiveness against organisms including Bacillus cereus spores.
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