Use of a hemocompatible porous polymer bead sorbent for removal of endotoxemia-inducing molecules
Inventors
Guliashvili, Tamaz • Golobish, Thomas • Gruda, Maryann • O'SULLIVAN, Pamela • SCHEIRER, Andrew • Capponi, Vincent • Chan, Phillip • Young, Wei-Tai
Assignees
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Publication Number
US-11826724-B2
Publication Date
2023-11-28
Expiration Date
Abstract
The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.
Core Innovation
The invention relates to a method of adsorbing toxins and inflammatory mediators by contacting physiologic fluid with a polymer system having either polyol or zwitterionic functionality. The polymer system is provided as a solid support having a polymer coating comprising one or more selected polymers, including poly(diethylaminoethyl methacrylate), poly(dimethylaminoethyl methacrylate), poly(hydroxyethyl acrylate), poly(hydroxyethyl methacrylate), poly(hydroxypropyl acrylate), poly(hydroxypropyl methacrylate), poly(N-vinylpyrrolidone), poly(vinyl alcohol), salts of poly(acrylic acid), salts of poly(methacrylic) acid, or mixtures thereof.
The polymer system is configured to adsorb endotoxemia-inducing and inflammatory species from physiologic fluid, including endotoxins (LPS) and inflammatory mediators. The targets described include broad classes of toxins and inflammatory mediators and can further include immunologically active substances such as cytokines and pattern molecules, as well as proteins, peptides, lipids, and toxins or antigens and antibodies.
The disclosed polymer system is also characterized in terms of porous solid support formats and pore-structure concepts, including the presence of multiple pores with total pore-volume and pore-size ranges. The disclosure additionally describes use in perfusion or hemoperfusion devices with packed bead beds and flow-through containers, optionally including in-line filtration, to contact physiologic fluid with the polymer-coated porous bead sorbent.
Claims Coverage
The document includes one independent claim directed to a method of adsorbing toxins and inflammatory mediators using a polymer system with either polyol or zwitterionic functionality, followed by dependent claims that add specific target ranges, additional polymer components, pore-structure constraints, and extracorporeal processing configuration.
Adsorbing toxins and inflammatory mediators using polyol or zwitterionic polymer functionality
A method of adsorbing toxins and inflammatory mediators comprising contacting physiologic fluid with a polymer system comprising either polyol or zwitterionic functionality.
Solid-support polymer coating selected from specified polymer materials
The polymer system has the form of a solid support having a polymer coating comprising poly(diethylaminoethyl methacrylate), poly(dimethylaminoethyl methacrylate), poly(hydroxyethyl acrylate), poly(hydroxyethyl methacrylate), poly(hydroxypropyl acrylate), poly(hydroxypropyl methacrylate), poly(N-vinylpyrrolidone), poly(vinyl alcohol), salts of poly(acrylic acid), salts of poly(methacrylic) acid, or mixtures thereof.
Target toxins and inflammatory mediators within a molecular-weight interval
The toxins and inflammatory mediators have a molecular weight from less than 0.5 kDa to 1,000 kDa.
Extracorporeal circuit processing with one or more passes
Passing physiologic fluid one or more times through an extracorporeal circuit includes a device with a polymer system.
Including heparin or a heparin-mimicking polymer in the polymer system
The polymer system includes either heparin or a heparin-mimicking polymer.
Porous polymer system with defined pore-size and pore-volume ranges
The polymer system has a plurality of pores with a total pore-volume of pore sizes between 10 Å and 40,000 Å that is greater than 0.1 cc/g and less than 5.0 cc/g of dry polymer.
Overall, the claims cover contacting physiologic fluid with a solid-support polymer coating that includes either polyol or zwitterionic functionality for adsorption of toxins and inflammatory mediators, with dependent claim limitations specifying molecular-weight ranges, optional inclusion of heparin or a heparin-mimicking polymer, defined pore-structure constraints, and extracorporeal processing via one or more passes.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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