Self-expanding devices and methods therefor
Inventors
Eaton, Donald J. • Huang, Bin • Abbate, Anthony J. • Zaler, Gail M. • Gale, David C.
Assignees
Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-11826494-B2
Publication Date
2023-11-28
Expiration Date
Abstract
Described here are delivery devices for delivering one or more implants to the body, and methods of using. The delivery devices may deliver implants to a variety of locations within the body, for a number of different uses. In some variations, the delivery devices have a cannula with one or more curved sections. In some variations, a pusher may be used to release one or more implants from the cannula. In some variations, one or more of the released implants may be a self-expanding device. Methods of delivering implants to one or more sinus cavities are also described here.
Core Innovation
The invention relates to a method of treating a patient by delivering a self-supported, wire-like expandable device to an ear region of the patient. The expandable device is configured to expand from a first compressed configuration to a second expanded configuration against tissue. The device includes one or more biodegradable polymer filaments formed into a repeating diamond-shaped pattern and is configured to release a drug.
In the disclosed implementations, drug release is achieved in combination with the biodegradable polymer filaments. The expandable device may include at least one biodegradable polymer filament having a drug-eluting layer, such that the expandable device releases the drug. The drug comprises a therapeutic agent selected from specified categories, including anti-inflammatory agents.
Claims Coverage
The independent claim specifies 3 inventive features: delivery of a self-supported, wire-like expandable device to an ear region, expansion against tissue from a compressed to an expanded configuration, and biodegradable polymer filaments in a repeating diamond-shaped pattern with drug release. Dependent claims refine these features by adding drug-eluting layers, narrowing the therapeutic agent categories, and adding drug release timing and daily dosage constraints, as well as specific biodegradable polymer composition details.
Ear-region delivery of a self-supported wire-like expandable device
Delivering a self-supported, wire-like expandable device to an ear region of the patient, wherein the expandable device is configured to expand from a first compressed configuration to a second expanded configuration against tissue.
Repeating diamond-shaped biodegradable polymer filament pattern
The expandable device comprises one or more biodegradable polymer filaments formed into a repeating diamond-shaped pattern.
Drug release from the expandable diamond-pattern device
The expandable device is configured to release a drug.
Drug-eluting layer on biodegradable polymer filaments
At least one biodegradable polymer filament is at least partially coated with a drug-eluting layer comprising the drug.
Therapeutic agent categories for the drug
The drug comprises a therapeutic agent selected from specified categories including anti-inflammatory agents.
Drug release over a defined time period
The expandable device releases the drug over a period of time between about 5 days and about 120 days.
Daily dosage limit for drug release
The expandable device releases the drug at a daily dosage of about 500 µg or less per day.
Biodegradable polymer filament material
At least one biodegradable polymer filament comprises poly(lactide-co-glycolide).
Overall claim coverage is anchored by treating a patient using an ear-region, self-supported wire-like expandable device that expands against tissue, uses biodegradable polymer filaments in a repeating diamond-shaped pattern, and is configured to release a drug; dependent claims further specify drug-eluting layers, therapeutic agent categories, release duration, daily dosage limits, and the inclusion of poly(lactide-co-glycolide).
Stated Advantages
Documented Applications
No documented applications found
Interested in licensing this patent?