Intraocular drug delivery platform
Inventors
Sussman, Glenn Robert • Cable, II, Craig Alan • Kahook, Malik Y.
Assignees
University of Colorado Colorado Springs • Spyglass Pharma Inc
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Publication Number
US-11813159-B2
Publication Date
2023-11-14
Expiration Date
Abstract
An intraocular drug delivery platform for use with an intraocular lens assembly. The platform includes a ring and haptics to maintain the ring in position in the capsular bag, compartments on the anterior surface of the ring for accommodating a drug eluting matrix or other drug mass, and a skirt extending posteriorly from the posterior surface of the ring to constrain movement, including lateral or inferior/superior movement, of the intraocular lens relative to the ring.
Core Innovation
The invention provides an intraocular drug delivery platform for use with an intraocular lens (IOL). The platform comprises a flat ring having an anterior surface, a posterior surface opposite the anterior surface, and a central aperture formed by the ring, with first and second drug eluting masses positioned on the anterior surface of the ring and the second drug eluting mass positioned directly opposite the first drug eluting mass.
The platform further includes a first haptic and a second haptic coupled to and extending outwards from the ring. The ring is centered in the capsular bag or ciliary sulcus by outwardly biased platform haptics, and the platform also includes a skirt extending posteriorly from the posterior surface of the ring and partially or fully circumscribing the central aperture.
The skirt comprises an inner diameter sized and configured to retain the IOL within the skirt. By constraining relative motion, the platform prevents migration toward the visual axis and limits lateral and inferior/superior motion. The drug eluting masses may include therapeutic agents coupled to the anterior surface of the ring and may be associated with matrices or polymers, with controlled elution using semi-permeable membranes or perforations.
Claims Coverage
One independent claim is identified. The independent claim includes four inventive features based on the platform structure and the paired opposed drug eluting masses.
Flat ring with central aperture for platform structure
A flat ring comprising an anterior surface, a posterior surface opposite the anterior surface, and a central aperture formed by the ring.
Paired outwardly extending haptics
A first haptic coupled to and extending outwards from the ring, and a second haptic coupled to and extending outwards from the ring.
Opposed first and second drug eluting masses on anterior surface
A first drug eluting mass comprising a therapeutic agent coupled to the anterior surface of the ring, and a second drug eluting mass comprising the therapeutic agent coupled to the anterior surface of the ring and positioned directly opposite of the first drug eluting mass.
Posterior skirt circumscribing aperture with inner diameter sized to retain IOL
A skirt extending posteriorly from the posterior surface of the ring and partially or fully circumscribing the central aperture, wherein the skirt comprises an inner diameter sized and configured to retain the IOL within the skirt.
Overall, the independent claim requires an intraocular drug delivery platform integrated with an IOL-retaining skirt and a paired-haptic, flat-ring structure featuring a central aperture and opposed first and second drug eluting masses coupled to the ring’s anterior surface.
Stated Advantages
Prevents migration toward the visual axis by constraining relative motion of the IOL within the skirt.
Limits lateral and inferior/superior motion.
Documented Applications
Intraocular drug delivery platform for use with an intraocular lens (IOL), configured to retain the IOL in a position by the intraocular drug delivery platform.
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