Systems and methods for remotely monitoring the cryogenic processing of samples
Inventors
Nancekievill, Alexander • RUTLEDGE, RUPERT
Assignees
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Publication Number
US-11802730-B2
Publication Date
2023-10-31
Expiration Date
Abstract
A remote system for monitoring and controlling one or more devices for use in the cryogenic processing of a sample is provided. A remote server capable of transmitting freezing profile data to one or more freezers, transmitting transportation profile data to one or more transportation devices, and transmitting thawing profile data to one or more thawing devices. The remote server is also capable of receiving detected data from the one or more freezers relating to the freezing of a sample in accordance with the freezing profile data, receiving detected data from the one or more transportation devices relating to the transportation of a sample in accordance with the transportation profile data, and receiving detected data from the one or more thawing machines relating to the thawing of a sample in accordance with the thawing profile data.
Core Innovation
A remote server is disclosed for remotely monitoring cryogenic processing of a sample by coordinating freezing, thawing, and transportation using predetermined profile data. The remote server transmits sample freezing profile data to at least one cryogenic freezer and receives detected freezer sensor data relating to freezing of the sample in accordance with the sample freezing profile data. The remote server also transmits the same sample freezing profile data to the at least one cryogenic freezer.
The remote server transmits sample thawing profile data to at least one thawing machine and receives detected thawing sensor data relating to thawing of the sample in accordance with the sample thawing profile data. In addition, the remote server transmits sample transportation profile data to at least one transportation device and receives detected transportation sensor data relating to transportation of the sample in accordance with the sample transportation profile data. The remote server is further configured to one or both of transmit or receive a same predetermined sample transportation profile data to or from the at least one transportation device.
The disclosed system includes a data store configured to store received data and supports remote access via a remote server with encrypted communications and near-real-time data transfer. The received detected data is used to generate stage-specific graphs and consistency reports across multiple devices and samples, and to support anomaly detection using server-added observations and alerting/annotation. The document further describes differential thermal analysis (DTA) performed on detected data, including processing power curves to estimate ice formation/heat release and heat capacity, and sample tracking using sample IDs with QC triggers during processing and transportation.
Claims Coverage
The partial content identifies one independent claim. The claim sets out a remote server that coordinates transmission of predetermined cryogenic freezing, thawing, and transportation profile data with receipt of detected sensor data for each processing stage, and stores the received data.
Remote server for cryogenic profile-driven monitoring
A remote server for remotely monitoring cryogenic processing of a sample configured to transmit sample freezing profile data to at least one cryogenic freezer and to receive detected freezer sensor data relating to freezing of the sample in accordance with the sample freezing profile data, and to transmit the same sample freezing profile data to the at least one cryogenic freezer; transmit sample thawing profile data to at least one thawing machine and receive detected thawing sensor data relating to thawing of the sample in accordance with the sample thawing profile data; transmit sample transportation profile data to at least one transportation device and receive detected transportation sensor data relating to transportation of the sample in accordance with the sample transportation profile data; and include a data store configured to store received data, wherein the remote server is further configured to one or both of transmit or receive a same predetermined sample transportation profile data to or from the at least one transportation device.
The independent claim covers a remote server that performs profile-driven, stage-specific monitoring by transmitting predetermined freezing, thawing, and transportation profile data to respective cryogenic processing devices, receiving corresponding detected sensor data in accordance with those profile data, and storing the received data, including handling a predetermined transportation profile data for one or both of transmitting and receiving with the transportation device.
Stated Advantages
Supports generation of stage-specific graphs and consistency reports across multiple devices and samples.
Supports anomaly detection with server-added observations and alerting/annotation.
Supports differential thermal analysis (DTA) on detected data, including ice formation/heat release and heat capacity estimation.
Documented Applications
Remote monitoring and control of cryogenic processing of a sample, including freezing, thawing, and transportation profiles and detected sensor data collection.
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