Extracorporeal oxygenation system for low flow rates and methods of use
Inventors
Ben NOON, Dagi • Shabtay, Abraham
Assignees
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Publication Number
US-11793919-B2
Publication Date
2023-10-24
Expiration Date
Abstract
This invention is directed to system and methods for the oxygenation of the blood of a patient, comprising an extracorporeal blood circulation path adapted to be coupled to the patient's vascular system, and comprising apparatus for oxygenating blood flowing therein and withdrawing CO2 therefrom, wherein the flow rate of blood flowing in said extracorporeal blood circulation path does not exceed ⅖ of the patient's blood flow. The extracorporeal blood circulation path preferably comprise a cartridge including an oxygenator and at least one cannula.
Core Innovation
An extracorporeal oxygenation system and methods are described for awake, spontaneously breathing patients using low blood flow rates to oxygenate blood and remove CO2. The system couples an extracorporeal blood circulation path to the patient vascular system through a disposable plug-and-play cartridge driven by a reusable base, and includes an oxygenator and cannula architecture intended to withdraw deoxygenated blood and return oxygenated blood.
The patent describes an integrated auto-priming system that uses a priming cap having an inlet and an outlet that are sealed from each other when mounted on a cannula. A saline repository and a priming pump comprising a drive unit and a replaceable priming pump head cooperate with sterile tubing to form a closed loop for fluid flow, and when the priming cap is fitted over lumens of the cannula, the inlet is placed in fluid communication with a first lumen and the outlet is placed in fluid communication with a second lumen such that air is evacuated from the closed loop.
The auto-priming operation is controlled so that priming occurs when the priming cap is fitted, while the cannula can be insertable into a patient vascular system when the priming cap is not fitted. The document further describes cartridge and blood path architecture including dual-lumen cannula lumens for drainage and infusion and an optional oxygenation module coupled to the extracorporeal path.
Claims Coverage
The partial content provided includes one independent claim. This claim covers automatic priming of at least one cannula using a sealed priming cap, a saline repository, a priming pump with a replaceable pump head, and a sterile-tubing closed-loop fluid path, coordinated by a controller to evacuate air when the cap is fitted.
Sealed priming cap forming closed-loop inlet/outlet communication
A priming cap including an inlet and an outlet that are sealed from each other when mounted on a cannula, where the priming cap is removably fittable over first and second lumens so that the inlet is in fluid communication with the first lumen and the outlet is in fluid communication with the second lumen.
Saline repository and replaceable priming pump head for automatic air evacuation
A saline repository and a priming pump comprising a drive unit and a replaceable priming pump head.
Sterile tubing closed-loop fluid path excluding the priming cap
A fluid path comprising sterile tubing between a first lumen and a second lumen of the at least one cannula, wherein the fluid path does not include the priming cap, such that the cannula, priming cap, saline repository, priming pump head, and fluid path form a closed loop for fluid flow when the priming cap is fitted.
Controller-operated priming pump when priming cap is fitted
A controller configured to operate the priming pump when the priming cap is fitted over the at least one cannula, thereby evacuating air from the closed loop; and when the priming cap is not fitted, the cannula is insertable into a patient vascular system.
Across the provided independent claim, the inventive aspects center on automatically priming at least one cannula by fitting a priming cap whose inlet and outlet are sealed from each other, using a saline repository and a priming pump with a replaceable pump head, and using a sterile-tubing closed-loop fluid path coordinated by a controller to evacuate air when the cap is fitted while allowing cannula insertion when the cap is not fitted.
Stated Advantages
Enables oxygenation of blood and removal of CO2 in awake, spontaneously breathing patients.
Auto-priming allows evacuation of air from a closed loop when the priming cap is fitted over the cannula.
Allows the cannula to be insertable into a patient vascular system when the priming cap is not fitted.
Documented Applications
Use in awake, spontaneously breathing patients for extracorporeal oxygenation to oxygenate blood and remove CO2.
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