Encapsulation of gastric residence systems
Inventors
Grant, Tyler • RYDE, Erik Robert Waldemar • KNOX, Raymond Patrick • BISHOFF, Megan
Assignees
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Publication Number
US-11793751-B2
Publication Date
2023-10-24
Expiration Date
Abstract
Compactable gastric residence systems comprising therapeutic agent formulations for sustained gastric release of therapeutic agents are disclosed, as well as methods and systems for encapsulating such gastric residence systems. Hie methods and systems for encapsulating the gastric residence systems can be automated from receiving a bulk of gastric residence systems, orienting, placing, compacting, securing, and encapsulating the gastric residence systems.
Core Innovation
The invention relates to compactable gastric residence systems for sustained gastric drug release, where the compactable gastric residence system includes a plurality of elongate members. Each elongate member has a proximal end attached to a linking member and a distal end not attached to the linking member. The distal end is located at a larger radial distance from the linking member than the proximal end, such that the system is capable of being compacted into a compacted form in which the distal ends come together.
The invention provides a method for encapsulating the compactable gastric residence system by receiving the system in an uncompacted form. The method includes orienting the compactable gastric residence system into a compacting position on a surface of a tapered tube having an aperture.
The compacting is performed by reducing a distance between the distal ends of each elongate member by applying a force to the linking member, causing the linking member and plurality of elongate members to pass through the aperture and to come together as a result of the passage through the aperture. After compaction, the method inserts the compacted gastric residence system into an opening of a container, such as a capsule or half-capsule.
Additional described arrangements include securing the compacted configuration using retaining elements and employing automated handling components for receiving, orienting, compacting, and inserting the compacted system into the container.
Claims Coverage
The document includes one independent claim directed to an encapsulation method for a compactable gastric residence system. The independent claim contains five core inventive features.
Receiving and orienting an uncompacted compactable gastric residence system
Receiving the compactable gastric residence system in an uncompacted form; orienting the compactable gastric residence system into a compacting position on a surface of a tapered tube having an aperture.
Compacting by reducing distal-end distance via tapered-tube aperture
Compacting the compactable gastric residence system into a compacted form by reducing a distance between the distal ends of each elongate member, by applying a force to the linking member and causing the linking member and plurality of elongate members to pass through the aperture, causing the distal end of each elongate member to come together.
Inserting the compacted form into a container opening
Inserting the compactable gastric residence system in the compacted form into an opening of a container.
Aperture radius smaller than container opening radius
Wherein the aperture has a radius smaller than a radius of an opening of the container.
Overall, the claim coverage centers on encapsulating a compactable gastric residence system by receiving it uncompacted, orienting it onto a tapered tube with an aperture, compacting by forcing the linking member and elongate members through the aperture so the distal ends come together, and then inserting the compacted system into a container opening where the aperture radius is smaller than the container opening radius.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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