Dual chamber syringe and methods of use thereof
Inventors
Benarous, Nir • Carmel, Ehoud • Raday, Lior • Daily, David • Keenan, Guy
Assignees
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Publication Number
US-11779705-B2
Publication Date
2023-10-10
Expiration Date
Abstract
A dual chamber syringe, comprising a syringe barrel having a forward end, a rearward end and at least one bypass protrusion arranged along the longitudinal extent of the syringe barrel; a finger grip element coupled to the rearward end of the syringe barrel, the finger grip comprises at least one protrusion extending radially inwardly from an inner surface thereof; a plunger rod operatively coupled with the finger grip element; a guiding track is formed on the plunger rod and comprises a helical track portion and a longitudinal track portion; and wherein upon relative displacement of the plunger rod and said finger grip element, the at least one protrusion is guided along the guiding track.
Core Innovation
A dual chamber syringe is provided with a syringe barrel having a forward end, a rearward end and at least one bypass protrusion arranged along a longitudinal extent of the syringe barrel. A finger grip element is coupled to the rearward end of the syringe barrel, and the finger grip comprises at least one protrusion extending radially inwardly from an inner surface of the finger grip element. A plunger rod is operatively coupled with the finger grip element and includes a guiding track formed on the plunger rod.
The guiding track comprises a helical track portion and a longitudinal track portion. The plunger rod is positionable in several operative orientations relative to the syringe barrel, including a storage, a pre-reconstitution, a reconstitution and an end of reconstitution operative orientation. Upon relative displacement of the plunger rod and the finger grip element, the at least one protrusion is guided along the guiding track, translating relative movement into staged operative orientations including storage, pre-reconstitution, reconstitution and end of reconstitution.
In the storage operative orientation, the at least one protrusion is axially spaced from the guiding track, and the plunger rod is rotatably displaceable relative to the finger grip element. In the storage operative orientation, the plunger rod is at least partially inserted into the finger grip element, with a forward end of the plunger rod disposed forwardly of the at least one protrusion. The bypass protrusion and the guiding-track guided protrusion enable solvent transferred through the bypass protrusion to mix with powder/drug preparation during reconstitution, coordinated with reconstitution and end-of-reconstitution operative orientations.
The syringe further implements a coordinated multi-piston arrangement including forward, intermediate and rearward pistons slidably arranged within the syringe barrel, with the rearward piston attached to the plunger rod. Coupling geometry coordinates pistons and the plunger rod during reconstitution and injection, including threadable attachment between the plunger rod and the rearward piston, and an alternate threading arrangement having different thread pitch and/or direction characteristics to prevent inadvertent disengagement. The guiding structure includes transitions including snap into a longitudinal track portion and configurations that prevent unwanted reverse rotation by providing guided coupling behavior associated with helical versus longitudinal track engagement.
Claims Coverage
The independent claim defines a dual chamber syringe with a barrel bypass protrusion, a finger grip having radially inward protrusions, and a plunger rod carrying a guiding track with helical and longitudinal portions that provide several operative orientations (storage, pre-reconstitution, reconstitution, end of reconstitution). The independent claim is supported by refinements in dependent claims that add a multi-piston architecture and define threadable versus axial displacement behavior, as well as specific coupling and threading constraints.
Guiding track with helical and longitudinal portions for staged operative orientations
A plunger rod has a guiding track comprising a helical track portion and a longitudinal track portion, where the plunger rod is positionable relative to the syringe barrel in operative orientations comprising a storage, a pre-reconstitution, a reconstitution and an end of reconstitution operative orientation, and where upon relative displacement the at least one radially inward protrusion is guided along the guiding track.
Storage operative orientation defines axially spaced protrusion and rotatably displaceable plunger rod
In the storage operative orientation, the at least one protrusion is axially spaced from the guiding track and the plunger rod is rotatably displaceable relative to the finger grip element, with the plunger rod at least partially inserted into the finger grip element and the forward end disposed forwardly of the at least one protrusion.
Bypass protrusion in barrel enabling dual chamber reconstitution coordination
The syringe barrel has at least one bypass protrusion arranged along a longitudinal extent, where the syringe is configured for reconstitution operative orientations using the bypass protrusion with staged guiding of the finger grip protrusion along the plunger-rod guiding track.
Conditional threadably displacement versus axially displacement based on track engagement
The plunger rod is configured for threadably displacement relative to the finger grip element when the at least one protrusion engages the helical track portion and for axially displacement relative to the finger grip element when the at least one protrusion engages the longitudinal track portion.
Three-piston architecture with rearward piston attached to plunger rod
The dual chamber syringe comprises a forward piston, an intermediate piston and a rearward piston slidably arranged within the syringe barrel, where the rearward piston is attached to the plunger rod.
Threaded mechanical coupling between inner plunger rod portion and rearward piston socket
An inner plunger rod portion includes an externally threaded protrusion extending from a forward end of the inner plunger rod portion, and the rearward piston includes an internally threaded socket adapted for threadable engagement with the externally threaded protrusion.
Different thread pitch or direction between couplings
The threading between the plunger rod and the rearward piston and the threading between the plunger rod and the finger grip element are different either in pitch or direction.
Overall, the independent claim structure is coverage of a dual chamber syringe that uses a plunger-rod guiding track with helical and longitudinal portions to guide radially inward finger-grip protrusions through multiple operative orientations, including a storage orientation defined by axial spacing and rotatable displacement. Dependent claims further narrow the behavior by specifying conditional threadable versus axially displacement depending on helical versus longitudinal engagement, and by adding a three-piston architecture with defined threaded couplings and constraints on differing thread pitch and/or direction.
Stated Advantages
Staged operative orientations including storage, pre-reconstitution, reconstitution and end of reconstitution.
Coordination of guided protrusion motion along helical and longitudinal track portions to support reconstitution operative orientations.
Prevention of inadvertent disengagement via different thread pitch and/or direction characteristics.
Documented Applications
No documented applications found
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