Stabilized intraocular drug delivery systems and methods of use

Inventors

Cable, II, Craig Alan • Kahook, Malik Y. • Sussman, Glenn R. • Maass, Sean

Assignees

University of Colorado Colorado Springs • Spyglass Pharma Inc

Abstract

Embodiments disclosed herein generally relate to a stabilized intraocular drug delivery system for implantation into an eye of a subject. The system can include an intraocular lens (IOL) assembly and a drug delivery component. The IOL assembly can include a lens and a haptic. The haptic can include an outer end, an inner end opposite the outer end, a retention tab at the inner end, and a connection tab positioned between the outer end and the inner end and adjoining the lens. The drug delivery component can include at least one therapeutic agent and a fixation portion having an opening to receive the haptic and secure the drug delivery component to the IOL assembly. The fixation portion of the drug delivery component can be secured to the connection tab of the haptic such that the retention tab inhibits movement of the drug delivery component relative to the IOL assembly.

Core Innovation

The invention provides a stabilized intraocular drug delivery system configured for implantation into an eye of a subject. The system includes an intraocular lens (IOL) assembly and a drug delivery component, where the IOL assembly comprises a lens and a haptic extending outwardly from the lens. The haptic is configured to engage the drug delivery component and includes an outer end, an inner end opposite the outer end, and a connection tab positioned between the outer end and the inner end and adjoining the lens.

In one form, stabilization is achieved by coupling a fixation portion of the drug delivery component to the connection tab such that movement of the drug delivery component relative to the IOL assembly is inhibited. The drug delivery component includes a drug delivery pad with one or more therapeutic agents, and a fixation portion coupled to the drug delivery pad. The fixation portion includes first and second structures extending from the drug delivery pad, a band coupled to the first and second structures, and an opening formed between the drug delivery pad, the first and second structures, and the band, the opening sized and dimensioned to receive the haptic while securing the drug delivery component.

The system further stabilizes the relative positioning by using fixation-geometry features that inhibit rotation and migration. Geometric cooperation between the fixation portion and the optic-haptic junction, including structural features such as a gusset and a relief cut at the optic-haptic junction, and cooperation between posts, a flexible band, and a retention tab, is described as inhibiting movement, rotation, and migration relative to the IOL.

In another form, the invention includes first and second indents configured to retain the drug delivery component in a position adjacent the lens and prevent outward movement therefrom. The first indent comprises a first concave surface adjoining the edge of the lens, and the second indent comprises a second concave surface adjoining the edge of the lens and positioned opposite of the first concave surface. A fixation portion of the drug delivery component includes an opening configured to receive the haptic therethrough and is secured to the first and second indents so outward movement relative to the lens is inhibited.

Claims Coverage

Two independent claims are present, and together they define stabilization of a drug delivery component relative to an intraocular lens using haptic-associated engagement and fixation features. The claim set emphasizes inhibition of relative movement, including outward movement relative to the lens, via geometrical coupling of an opening and haptic, with stabilization further constrained by indent and concave-surface retention geometry.

The independent claims cover stabilization of an intraocular drug delivery component by securing a fixation portion opening to a haptic connection tab with a geometry that inhibits relative movement, including outward movement; and using first and second indents with concave surfaces on the haptic to retain the drug delivery component adjacent the lens and prevent outward movement.

Stated Advantages

Documented Applications