Systems and methods for collecting and screening of pancreatic secretions
Inventors
Duan, Xiaodong • Xiao, Guohua • Rubey, Kevin
Assignees
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Publication Number
US-11771311-B2
Publication Date
2023-10-03
Expiration Date
Abstract
Disclosed here are systems and methods for collecting and/or screening of a pancreatic secretion, using a capsule endoscope comprising an imaging system and a trypsin sensor, and a tether coupled to the capsule endoscope.
Core Innovation
The invention provides a capsule endoscope system that includes an imaging system and a trypsin sensor. The trypsin sensor is configured to detect trypsin in a fluid that is in contact with the sensor, and the sensor uses a substrate comprising a polymeric film and a dye selected from bromocresol purple dye, 3′,5,5′-tetramethyl benzidine dye, triarylmethane dye, xylenol orange dye, and metal complex dye.
The polymeric film comprises bromobutane and vinylimidazole at a molar ratio between 2:1 and 1:1 bromobutane to vinylimidazole. In a further system, the polymeric film additionally comprises acrylonitrile such that the mass of acrylonitrile is greater than or equal to the sum of the masses of bromobutane and vinylimidazole.
The sensor is connected to a tether that includes a flexible member having a lumen, and the flexible member is in fluidic communication with the capsule endoscope. A method advances the capsule endoscope into a gastrointestinal tract, positions the capsule endoscope at a region of interest, detects trypsin in a fluid contacting the trypsin sensor, and withdraws a sample from the region of interest through the lumen.
Claims Coverage
The document contains two independent claims for a system and one independent claim for a method. Across these independent claims, there are inventive features related to a capsule endoscope with an imaging system, a trypsin sensor with a polymeric film substrate and specifically selected dye chemistry, defined polymer composition constraints for the film, and tether-based fluidic communication for positioning and sample withdrawal.
Imaging capsule with trypsin sensor on polymeric film and selected dye
A capsule endoscope comprising an imaging system and a trypsin sensor configured to detect trypsin in a fluid that is in contact with the trypsin sensor, the trypsin sensor comprising a substrate comprising a polymeric film and a dye selected from bromocresol purple dye, 3′,5,5′-tetramethyl benzidine dye, triarylmethane dye, xylenol orange dye, and metal complex dye.
Polymeric film composition constrained by bromobutane and vinylimidazole molar ratio
The polymeric film comprises bromobutane and vinylimidazole at a molar ratio between 2:1 and 1:1 bromobutane to vinylimidazole.
Tether with lumen fluidically communicating with the capsule endoscope
A tether comprising a flexible member comprising a lumen, wherein the flexible member is in fluidic communication with the capsule endoscope.
Method using positioned capsule endoscope to detect trypsin and withdraw sample through tether lumen
A method comprising advancing a capsule endoscope into a gastrointestinal tract of a patient, positioning the capsule endoscope at a region of interest, detecting trypsin in a fluid that is in contact with the trypsin sensor, and withdrawing a sample from the region of interest through the lumen, wherein the capsule endoscope comprises an imaging system and a trypsin sensor and the trypsin sensor uses a substrate comprising a polymeric film comprising bromobutane and vinylimidazole at a molar ratio between 2:1 and 1:1.
System with trypsin sensor polymeric film additionally constrained by acrylonitrile mass
A capsule endoscope system comprising an imaging system and a trypsin sensor configured to detect trypsin in a fluid that is in contact with the trypsin sensor, wherein the polymeric film comprises bromobutane, vinylimidazole, and acrylonitrile, and wherein the mass of acrylonitrile is greater than or equal to the sum of the masses of bromobutane and vinylimidazole, and a tether comprising a flexible member comprising a lumen in fluidic communication with the capsule endoscope.
Across the independent claims, coverage centers on a capsule endoscope with an imaging system and a trypsin sensor based on a polymeric-film substrate and a dye selected from a defined set, with the polymer film composition constrained by bromobutane/vinylimidazole molar ratio and, in the alternative system, by acrylonitrile mass relative to the other components. The claims further require a tether with a lumen in fluidic communication with the capsule endoscope, enabling positioning at a region of interest, trypsin detection in a contacting fluid, and sample withdrawal through the lumen.
Stated Advantages
Non-invasive.
Reduced complication risk.
Ease/cost/scale-up of the sensor.
Documented Applications
Detecting trypsin in a fluid containing pancreatic secretion to identify the location of the duodenal papilla and withdrawing a sample from a region of interest through the tether lumen.
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