Database, data structures, and data processing systems for recommending clinical trial sites

Inventors

Stockton, Gwendolyn • Marino, Jehan • Kohegyi, Eva • Gidner, Judi • Derendorf, Kevin

Assignees

Otsuka America Pharmaceutical Inc

Abstract

Methods, systems, and apparatuses, including computer programs, for generating a recommendation of candidate clinical trial sites. In one aspect, the method can include receiving parameters of a clinical trial, filtering, based on the received parameters, database data to obtain a filtered set of location-prescription pairs, generating a location-prescription data structure for each location-prescription pair, determining a ranking score, for each location-prescription pair, based on one or more prioritization parameters, identifying a subset of locations based on the respective ranking scores, obtaining a portion of map data from a map database that corresponds to a geographic region that is defined based on the identified subset of locations, and generating rendering data that, when rendered by a user device, causes the user device to render a visualization that includes (i) the obtained portion of the map data and (ii) data identifying the subset of locations on a display of a computer device.

Core Innovation

The invention provides a data processing system and method for generating a visualization that presents a recommendation of one or more candidate sites for a clinical trial. A request for a clinical trial site includes data representing one or more parameters of the clinical trial, and the system receives that request using one or more processors or one or more computers. The system executes a first query against a first database storing data records describing attributes of historical clinical trials using first query parameters based on the clinical trial parameters.

The system then executes a second query against a second database storing data records describing locations where prescriptions are being filled for a particular disease, using second query parameters based on the obtained attributes of the historical clinical trials that satisfy the first query. From the executed first query and the executed second query, the system obtains a set of location-prescription pairs. For each location-prescription pair, the system generates a location-prescription data structure and generates a ranking score for each pair based on one or more prioritization parameters.

Based on the ranking scores, the system identifies a subset of one or more locations that correspond to each location-prescription pair in the set of location-prescription pairs. The system then generates rendering data that, when rendered by a user device, causes the user device to render a visualization based on the identified subset. The visualization presents a recommendation of the candidate sites for the clinical trial using the subset of locations derived from the ranking.

Claims Coverage

The independent claims identify a small set of core inventive features: receiving a clinical trial site recommendation request with clinical trial parameters; querying historical clinical trials; querying locations where prescriptions are being filled and forming location-prescription pairs; generating location-prescription data structures; generating ranking scores from prioritization parameters; selecting a subset of locations based on ranking; and generating rendering data for a user device visualization.

Across the independent claims, the claim coverage centers on forming location-prescription pairs from historical clinical trial attributes and prescription-fill location data, scoring each pair using prioritization parameters to select a subset of locations, and generating rendering data so a user device renders a visualization recommending one or more candidate clinical trial sites.

Stated Advantages

Documented Applications