Hemocompatibility modifiers for cross-linked polymeric material
Inventors
Golobish, Thomas D. • Capponi, Vincent J. • Clay, David R.
Assignees
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Publication Number
US-11752250-B2
Publication Date
2023-09-12
Expiration Date
Abstract
The invention concerns methods of treating blood, blood product, or physiologic fluid to provide at least one of (i) increasing shelf life of the blood, blood product or physiologic fluid, (ii) maintaining freshness of new blood, blood product or physiologic fluid, and (iii) removing undesirable molecules from the blood, blood product or physiologic fluid; said method comprising contacting said blood, blood product or physiologic fluid with a sorbent, said sorbent being primarily in a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of at least one of (1) zwitterionic moieties and (2) oligo(ethylene glycol) moieties attached to the surface of said cross-linked polymeric material.
Core Innovation
The document describes treating blood, blood product, plasma, or physiologic fluid by contacting the fluid with a sorbent to provide increased shelf life. The sorbent comprises a cross-linked polymeric material having a plurality of ligands attached to the surface of the cross-linked polymeric material, and the surface-attached ligands comprise zwitterionic moieties, oligo(ethylene glycol) moieties, or mixtures thereof.
The zwitterionic moieties include carboxybetaine and/or sulfobetaine zwitterionic moieties, and the oligo(ethylene glycol) moieties are included as oligo(ethylene glycol) moieties, including oligo(ethylene glycol) methacrylate (OEGMA). The contacting is configured to sorb inflammatory mediators and stimulators, including when the sorbent is within a cartridge suitable for filtration of blood, blood product or physiologic fluid, or when the sorbent is placed within a storage bag suitable for storing blood, blood product or physiologic fluid.
The sorbent is substantially free-flowing within the cartridge or storage bag, and the sorbent particles are characterized by a specified diameter range and a pore-structure and pore-volume distribution.
Claims Coverage
The independent claim covers one inventive feature centered on a method of treating blood-related fluids to increase shelf life by contacting the fluid with a specified cross-linked polymeric sorbent having surface-attached zwitterionic and/or oligo(ethylene glycol) ligands, configured for use in a cartridge filtration unit and/or a storage bag, with specific particle diameter and pore-structure constraints.
Shelf-life increasing contacting with a surface-ligand sorbent
A method of treating blood, blood product, plasma or physiologic fluid to provide increased shelf life by contacting the fluid with a sorbent comprising a cross-linked polymeric material having surface-attached ligands comprising zwitterionic moieties, oligo(ethylene glycol) moieties, or mixtures thereof.
Cartridge filtration and storage bag contacting for inflammatory mediator sorption
The contacting sorbs inflammatory mediators and stimulators when the sorbent is within a cartridge suitable for filtration of blood, blood product or physiologic fluid or placed within a storage bag suitable for storing blood, blood product or physiologic fluid, wherein the sorbent is substantially free-flowing within the cartridge or storage bag.
Specific particle diameter and pore-structure distribution
The sorbent comprises particles having a diameter in the range of 0.1 micrometers to 2 centimeters and characterized by a pore structure with a total pore volume and specified pore-volume ratios across multiple pore-size ranges as defined for the cross-linked polymeric material.
Broad inflammatory mediator and stimulator selection for sorption
The inflammatory mediators and stimulators are selected from cytokines, thromboxanes, leukotrienes, platelet-activating factor, prostaglandins, glycoproteins, kinins, kininogens, complement factors, cell-adhesion molecules, superantigens, monokines, chemokines, interferons, free radicals, proteases, arachidonic acid metabolites, prostacyclins, beta endorphins, myocardial depressant factors, tetrahydrobiopterin, bradykinin, soluble CD40 ligand, hemoglobin, red cell particulates, membrane or cellular components, growth factors, prions, toxins, endotoxins, vasoactive substances, foreign antigens, microvesicles and antibodies.
Cross-linked polymeric material derived from specified polymerizable monomers
The sorbent comprises cross-linked polymeric material derived from the reaction of a cross-linker with one or more polymerizable monomers selected from divinyl-benzene, styrene, ethylstyrene, acrylonitrile, butyl methacrylate, octyl methacrylate, butyl acrylate, octyl acrylate, cetyl methacrylate, cetyl acrylate, ethyl methacrylate, ethyl acrylate, vinyltoluene, vinylnaphthalene, vinylbenzyl alcohol, vinylformamide, methyl methacrylate, and methyl acrylate.
Carboxybetaine and sulfobetaine zwitterionic moieties
The zwitterionic moieties comprise one or more carboxybetaine and sulfobetaine zwitterionic moieties.
The claim coverage centers on a shelf-life increasing method using a substantially free-flowing, surface-ligand cross-linked polymer sorbent with defined particle diameter and pore-volume distribution, used in a cartridge and/or storage bag to sorb a broadly enumerated set of inflammatory mediators and stimulators.
Stated Advantages
Increased shelf life of the blood, blood product or physiologic fluid.
Documented Applications
Use of the sorbent within a cartridge suitable for filtration of blood, blood product or physiologic fluid.
Placement of the sorbent within a storage bag suitable for storing blood, blood product or physiologic fluid.
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