Method and system for treating movement disorders
Inventors
Chang, Pin • Chen, Hsin • Chang, Yen-Chung • Yeh, Shih-Rung
Assignees
Biopro Scientific Co Ltd • National Tsing Hua University NTHU
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Publication Number
US-11745013-B2
Publication Date
2023-09-05
Expiration Date
Abstract
A method for treating movement disorders is provided. The method includes the following operations. A central nervous signal of a patient with movement disorders is recorded. A first stimulation is delivered from a stimulator to the patient when an oscillation episode in a range of from about 3 Hz to about 20 Hz is observed in the central nervous signal. The first stimulation is adapted according to a measurable feature of the oscillation episode. The system for treating movement disorders is also provided.
Core Innovation
The disclosed invention records a central nervous signal of a patient with Parkinson's disease and identifies an onset of an oscillation episode from the central nervous signal. The oscillation episode is defined as a High-Voltage Spindle (HVS) signal having an oscillation frequency in a range of about 5 Hz to about 13 Hz.
When the onset of the oscillation episode is identified, the invention delivers a first stimulation from a stimulator to the patient. The first stimulation is applied during a course of the oscillation episode and is terminated when the HVS signal is decaying to a lower threshold, terminated, or after the HVS signal has been terminated for 1.0 to 2.0 seconds.
The invention further adapts the first stimulation according to a measurable feature of the oscillation episode. The measurable feature is derived from the oscillation episode and includes oscillation intensity, oscillation frequency, oscillation duration, frequency of occurrence, and energy derived from the oscillation episode.
Claims Coverage
The partial content provides one independent claim that defines a closed-loop treatment method for Parkinson's disease. The inventive features center on detection of HVS onset in a 5 to 13 Hz range, delivery of stimulation during the episode with defined termination criteria, and adaptation based on measurable oscillation features.
Onset detection of HVS oscillation episode (5 to 13 Hz)
Record a central nervous signal of a patient with Parkinson's disease and identify an onset of an oscillation episode from the central nervous signal, wherein the oscillation episode is a High-Voltage Spindle (HVS) signal having an oscillation frequency in a range of from about 5 Hz to about 13 Hz.
Stimulation during the HVS episode with defined termination
Deliver a first stimulation from a stimulator to the patient when the onset of the oscillation episode is identified from the central nervous signal, apply the first stimulation during a course of the oscillation episode, and terminate the first stimulation when the HVS signal is decaying to a lower threshold, terminated, or after the HVS signal has been terminated for 1.0 to 2.0 seconds.
Adaptive stimulation based on measurable oscillation features
Adapt the first stimulation according to a measurable feature of the oscillation episode.
Overall, claim coverage centers on detecting the onset of an HVS oscillation episode within a specified 5 to 13 Hz frequency range, delivering a first stimulation during the episode with defined termination criteria, and adapting stimulation based on measurable features of the oscillation episode.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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