Diagnostics systems and methods
Inventors
Galen, Peter • GURKAN, UMUT ATAKAN • HASAN, MUHAMMAD NOMAN • Bledsoe, James Daren • Witte, Tyler
Assignees
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Publication Number
US-11740203-B2
Publication Date
2023-08-29
Expiration Date
Abstract
A diagnostic system that includes a cartridge and a reader is discussed herein. The cartridge can contain a patient sample, such as a blood sample. The cartridge is inserted into the reader and the patient sample is analyzed. The reader contains various analysis systems, such as an electrophoresis detection system that uses electrophoresis testing to identify and quantify various components of the blood sample. The reader can process data from the various patient sample analysis to provide interpretative results indicative of a disorder, condition, disease, or infection of the patient.
Core Innovation
The invention relates to an electrophoresis detection system that uses illumination with first and second wavelengths during an assay run on an electrophoresis strip. The illumination source emits a first stimulus at a first wavelength and a second stimulus at a second wavelength, and processing circuitry generates an instruction to cause emission of both stimuli.
The system receives multiple optical images of the electrophoresis strip captured during the assay run at first and second time points corresponding to the emission of the first and second stimuli. Based on the multiple optical images, processing circuitry detects band detection data using first and second detection characteristics generated from the first and second images, where each detection characteristic includes band thickness and band speed of both a first band and a second band.
Using the first and second detection characteristics, the system identifies a component associated with the band detection data and transmits an identifier of the component to an output during the assay run. The optical imaging and wavelength-selective stimulation architecture supports component identification from band thickness and band speed derived from images acquired at different stimuli wavelengths and time points.
Claims Coverage
The partial content contains one independent claim with multiple inventive features in combination: wavelength-selective stimulus emission, multi-time-point multi-wavelength optical imaging, band detection characteristic extraction including band thickness and band speed, component identification, and transmission of a component identifier to an output. Dependent claims further refine detection characteristics, band/intensity comparisons, assay effectiveness handling, and specificity to wavelengths and stains.
Wavelength-selective illumination stimuli during an assay run
The illumination source emits a first stimulus having a first wavelength and a second stimulus having a second wavelength during the assay run on the electrophoresis strip, and processing circuitry generates an instruction to cause emission of the first and second stimuli.
Multi-image capture at stimulus-corresponding time points
The processing circuitry receives multiple optical images of the electrophoresis strip, with a first image captured at a first time point during the assay run when the first stimulus is emitted and a second image captured at a second time point during the assay run when the second stimulus is emitted.
Band detection characteristics including thickness and speed
The processing circuitry detects band detection data based on the multiple optical images, where a first detection characteristic generated from the first image includes band thickness and band speed of both a first band and a second band, and a second detection characteristic generated from the second image includes band thickness and band speed of both the first band and the second band.
Component identification from detection characteristics
During the assay run, the processing circuitry identifies a component associated with the band detection data based on the first characteristic and the second characteristic.
Transmission of a component identifier to an output
During the assay run, the processing circuitry transmits an identifier of the component to an output.
Overall claim coverage centers on a combined illumination, imaging, detection, and identification pipeline for an electrophoresis assay strip.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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