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Assignees
Member
CrossjectCrossject is a specialty pharmaceutical company focused on drug-device combination products for emergency medicine. Leveraging a proprietary needle-free auto-injection platform, the company develops and manufactures fast-acting treatments for life-threatening situations such as epilepsy, adrenal crisis, and anaphylaxis. Crossject conducts advanced regulatory development, clinical validation, and large-scale industrialization to deliver innovative therapies for global markets, with an emphasis on simplicity, reliability, and patient usability.
Crossject is a specialty pharmaceutical company focused on drug-device combination products for emergency medicine. Leveraging a proprietary needle-free auto-injection platform, the company develops and manufactures fast-acting treatments for life-threatening situations such as epilepsy, adrenal crisis, and anaphylaxis. Crossject conducts advanced regulatory development, clinical validation, and large-scale industrialization to deliver innovative therapies for global markets, with an emphasis on simplicity, reliability, and patient usability.
Publication Number
US-11738151-B2
Publication Date
2023-08-29
Expiration Date
Abstract
A needleless injection device is provided that includes a body forming a housing, a gas generator, a tubular reservoir that contains an active ingredient, and a T-shaped elastically deformable membrane having a tubular portion. The reservoir extends axially in the housing from an upper end to a lower end and the tubular portion is configured to extend and lie axially in the reservoir under an effect of a pressure generated by the gas generator. An injection nozzle is arranged at the lower end of the reservoir. The tubular portion is funnel shaped and includes at least an upper segment that decreases along an axial elongation direction of the member and a lower segment that increases along the axial elongation direction. The axial length of the upper segment is greater than that of the lower segment.
Core Innovation
The invention relates to a needleless injection device that includes a gas generator, a tubular reservoir extending axially in a housing, and an injection nozzle arranged at the lower end of the tubular reservoir. The tubular reservoir contains an active ingredient to be injected, and a T-shaped elastically deformable membrane deformably extends and lies axially in the tubular reservoir under an effect of pressurized gas generated by the gas generator.
The membrane includes a tubular portion that is funnel shaped and includes an upper segment and a lower segment with contiguous curved frustoconical shapes. In the undeformed state, the upper segment has a decreasing curved frustoconical shape along the direction of axial elongation, and the lower segment has an increasing curved frustoconical shape contiguous with the upper segment.
A substantially curved bottom delimits a radial space with an inner wall of the reservoir. The bottom includes upper and lower portions that contact the inner wall and extend along a diameter of the housing, and an intermediate portion between the upper and lower portions.
Claims Coverage
The independent claim coverage includes three independent claim sets. Across them, the core inventive aspects are a needleless injection device architecture using a gas generator and an axially extending tubular reservoir, together with a T-shaped elastically deformable membrane having a funnel-shaped tubular portion with contiguous curved frustoconical segments and a substantially curved bottom that delimits a radial space.
Gas generator needleless injection with axially extending tubular reservoir and nozzle
A needleless injection device with a body forming a housing, a gas generator, a tubular reservoir extending axially in the housing containing an active ingredient to be injected with an upper end and a lower end, and an injection nozzle arranged at the lower end of the tubular reservoir.
T-shaped elastically deformable funnel-shaped membrane with contiguous decreasing and increasing curved frustoconical segments
A T-shaped elastically deformable membrane comprising a tubular portion configured to deformably extend and lie axially in the tubular reservoir under an effect of pressure generated by the gas generator, where the tubular portion is funnel shaped and includes an upper segment with a curved frustoconical decreasing section and a lower segment with a curved frustoconical increasing section contiguous with the upper segment.
Substantially curved membrane bottom delimiting radial space at the reservoir inner wall
A membrane bottom having a substantially curved shape that delimits a radial space with an inner wall of the reservoir, where the bottom includes upper and lower portions contacting the inner wall and extending along a diameter of the housing, and an intermediate portion between the upper and lower portions with the radial space delimited between the inner wall and the intermediate portion.
Membrane made of ethylene-propylene-diene monomer
The membrane is made of ethylene-propylene-diene monomer.
The independent claims define a needleless injection device driven by a gas generator that pressurizes an axially extending tubular reservoir through a T-shaped elastically deformable funnel-shaped membrane. The membrane’s tubular portion is characterized by contiguous curved frustoconical upper and lower segments, and the membrane bottom has a substantially curved shape delimiting a radial space relative to the reservoir inner wall. One independent set further specifies the membrane material as ethylene-propylene-diene monomer.
Stated Advantages
The device is described with membrane material and structural relationships intended to reduce membrane/reservoir friction and promote axial extension and piston-driven injection through the nozzle.
Documented Applications
Needleless injection of an active ingredient.
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