Adherent resorbable matrix
Inventors
Pomrink, Gregory J. • Alkema, Paul K. • Hubbard, Raymond D. • Menon, Riyesh
Assignees
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Publication Number
US-11724010-B2
Publication Date
2023-08-15
Expiration Date
Abstract
The present invention is directed to an adherent resorbable matrix for use in surgical applications. The adherent resorbable matrix includes a biocompatible adherent material including chitosan.
Core Innovation
The invention relates to an adherent resorbable porous device for regenerating tissue in a patient. The device includes a biocompatible and resorbable collagen matrix sheet that has pores of sizes that permit growing tissue to infiltrate therein, and a porous structure that facilitates ingrowth of cells into the collagen matrix.
The device includes an adhesive layer formed as a dried adhesive on only one surface of the collagen matrix sheet. When the dried adhesive contacts aqueous fluid, it provides adherence to a surface of the tissue and allows infiltration of cells of the tissue into the collagen matrix sheet.
The adhesive is selected from hydroxypropyl methyl cellulose, hydroxyethyl cellulose, and combinations thereof, and the adhesive layer thickness is from 0.10 mm to 1 mm. The invention also encompasses a method of making the biocompatible and resorbable matrix by applying a solution of adhesive to only one surface of a collagen matrix sheet and lyophilizing to form the dried adhesive layer.
The invention further includes a method for preventing migration of a biocompatible and resorbable matrix during surgery by placing the adherent resorbable porous device over tissue and allowing contact with aqueous fluid.
Claims Coverage
The independent claims include a device claim and two independent method claims. Across the claims, the inventive coverage centers on a porous collagen matrix permitting cell infiltration, a dried adhesive layer on only one collagen surface that adheres upon aqueous contact, defined adhesive thickness, specific adhesive selections, and lyophilization-based formation of the dried adhesive layer.
Adherent resorbable porous tissue-regeneration collagen matrix with pores permitting infiltration
A biocompatible and resorbable collagen matrix sheet having pores of sizes that permit growing tissue to infiltrate therein, with a porous structure that facilitates ingrowth of cells into the collagen matrix.
Dried adhesive layer on only one surface that adheres upon aqueous fluid contact
An adhesive layer having a thickness from 0.10 mm to 1 mm of a dried adhesive on only one surface of the collagen matrix sheet, which when contacted with aqueous fluid provides adherence to a surface of the tissue and allows infiltration of cells of the tissue into the collagen matrix sheet.
Hydroxypropyl methyl cellulose or hydroxyethyl cellulose as the dried adhesive
The adhesive is selected from hydroxypropyl methyl cellulose, hydroxyethyl cellulose, and combinations thereof.
Preventing migration of the resorbable matrix during surgery by aqueous contact adherence
Placing the adherent resorbable porous device over tissue and allowing contact with aqueous fluid to prevent migration of the biocompatible and resorbable matrix during surgery.
Making the adherent resorbable porous matrix by applying adhesive to one surface and lyophilizing
Applying a solution of adhesive to only one surface of a collagen matrix sheet and lyophilizing to form an adhesive layer of dried adhesive that, when contacted with aqueous fluid, provides adherence to a surface of the tissue and allows infiltration of cells into the collagen matrix.
Across the independent claims, the coverage is directed to an adherent resorbable porous collagen matrix device and associated methods. The key inventive elements are the porous collagen matrix that permits infiltration and ingrowth, and a dried adhesive layer on only one surface that provides adherence upon aqueous fluid contact and supports cell infiltration, using hydroxypropyl methyl cellulose and/or hydroxyethyl cellulose.
Stated Advantages
Facilitates ingrowth of cells into the collagen matrix.
Provides adherence to a surface of the tissue when contacted with aqueous fluid.
Allows infiltration of cells of the tissue into the collagen matrix sheet.
Minimizes migration of the biocompatible and resorbable matrix during surgery.
Documented Applications
Dural substitute for repairing dural defects in neurosurgery.
Tissue regeneration in a patient, including in vivo placement over tissue during surgery.
Orthopedic applications.
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