Injection nozzle for a needleless injection device
Inventors
AURIEL, Christophe • Alexandre, Patrick • Guichard, Benoit • ASCANI, Jennifer • Tazibt, M. Abdel
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Assignees
Member
CrossjectCrossject is a specialty pharmaceutical company focused on drug-device combination products for emergency medicine. Leveraging a proprietary needle-free auto-injection platform, the company develops and manufactures fast-acting treatments for life-threatening situations such as epilepsy, adrenal crisis, and anaphylaxis. Crossject conducts advanced regulatory development, clinical validation, and large-scale industrialization to deliver innovative therapies for global markets, with an emphasis on simplicity, reliability, and patient usability.
Crossject is a specialty pharmaceutical company focused on drug-device combination products for emergency medicine. Leveraging a proprietary needle-free auto-injection platform, the company develops and manufactures fast-acting treatments for life-threatening situations such as epilepsy, adrenal crisis, and anaphylaxis. Crossject conducts advanced regulatory development, clinical validation, and large-scale industrialization to deliver innovative therapies for global markets, with an emphasis on simplicity, reliability, and patient usability.
Publication Number
US-11712521-B2
Publication Date
2023-08-01
Expiration Date
Abstract
An injection nozzle for a needleless injection device includes at least one outlet conduit extending parallel to an injection axis (B). The outlet conduit(s) include a first conduit portion having a first section, a second conduit portion having a second section, the first section being larger than the second section, and a connecting portion between the first conduit portion and the second conduit portion. The connecting portion is inclined at an angle between 70° and 90° with respect to the injection axis (B).
Core Innovation
The disclosure relates to a needleless injection device comprising a gas generator, a plunger actuated by the gas generator, and a reservoir configured to receive a fluid to be injected, with the plunger configured to eject the fluid out of the reservoir. At least one injection nozzle is fluidly connected to the reservoir and is configured to guide the fluid out of the needleless injection device. The injection nozzle includes at least one monolithic outlet conduit extending parallel to an injection axis and configured to let the fluid pass when expelled.
The outlet conduit comprises a first conduit portion having a first section with a first fluid flow area larger than a second fluid flow area of a second section. A second conduit portion is integral with the first conduit portion and has the second section, with a connecting portion between the first conduit portion and the second conduit portion. The connecting portion is inclined at an angle comprised between 70° and 90° with respect to the injection axis, optionally at 80° to 90° or perpendicular.
The gas generator extends along an axis that is offset from the injection axis. The needleless injection device further includes a cap mounted about the injection axis between a closure position in which the cap is locked and an open position in which access is allowed to carry out an injection, where the cap includes a passage at least partially receiving the at least one injection nozzle and is closed by a removable disk.
Claims Coverage
The independent claim includes two core inventive aspects: a stepped monolithic outlet conduit with a connecting portion inclined 70° to 90° relative to the injection axis, and a needleless gas-generator-driven injection device having an offset gas-generator axis together with a cap and removable disk providing access to the nozzle.
Stepped monolithic outlet conduit with inclined connecting portion
A needleless injection device includes at least one injection nozzle comprising at least one monolithic outlet conduit configured to let the fluid pass when expelled, the outlet conduit extending parallel to an injection axis; the outlet conduit includes a first conduit portion with a first section having a first fluid flow area larger than a second fluid flow area of a second section; a second conduit portion integral with the first conduit portion having the second section; and a connecting portion between the first conduit portion and the second conduit portion, where the connecting portion is inclined at an angle comprised between 70° and 90° with respect to the injection axis.
Gas generator axis offset with cap and removable disk access
The needleless injection device has a gas generator extending along an axis offset from the injection axis, and further includes a cap mounted about the injection axis between a closure position and an open position; the cap includes a passage at least partially receiving the at least one injection nozzle and closed by a removable disk to allow access to carry out an injection.
Across the independent claim, the inventive coverage focuses on the stepped/integral monolithic outlet conduit aligned to the injection axis with an inclined connecting portion (70°–90°), and on a gas-generator-driven device whose gas-generator axis is offset from the injection axis while a cap with a removable disk provides nozzle access.
Stated Advantages
Improves fluid-jet coherence length.
Yields higher outlet speed for the same gas pressure.
More tolerant to manufacturing defects.
Cheaper and easier to make.
Documented Applications
Needleless injection device use for injecting fluids containing active ingredients into a user, including injection carried out with the cap moved between a closure position and an open position.
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