System for collection and analysis of biofluid from skin and method of using the same

Inventors

Wildhaber, Fabien Patrick • Ebejer, Neil • Guérin, Hoël Maxime • Longo, Johan Frédéric

Assignees

Xsensio SA

Abstract

Presented herein are systems, methods for collecting fluid from a surface (e.g., skin) and analyzing the fluid (e.g., to measure chemical, physical and/or biological properties of the fluid). For example, a system for fluid collection on a surface (e.g., skin) and fluid analysis includes at least one of the following modules: (i) a collection and delivery module to collect a fluid over a wet or partially wet surface and deliver it to (ii) a main sensing module to perform chemical, physical and/or biological analysis on the fluid. The system also includes (iii) a flow regulation module, for controlling fluid flow (e.g., transport) through the system and (iv) a waste module to collect and/or dispose of the fluid after analysis is complete.

Core Innovation

A system for collection and analysis of a biofluid from skin includes a collection and delivery module, a sensing module, a passive flow regulation module, and a waste module. The collection and delivery module collects the biofluid from the skin and transports the biofluid to the sensing module, and the sensing module determines one or more chemical and/or physical properties of the biofluid. After the analysis is complete, the waste module collects and disposes of the biofluid.

The passive flow regulation module comprises a surface property barrier and a capillary pump disposed after the surface property barrier along a direction of flow of the biofluid through the system. The flow regulation module is positioned between the sensing module and the waste module along the direction of flow. This arrangement provides controlled flow of the biofluid through the system while enabling the sensing module to determine chemical and/or physical properties.

The wearable system further integrates a microfluidic channel network and sensing components, including electrochemical/electrical/optical sensors and sensor arrays such as ISFET/FET arrays with functionalized sensor surfaces and reference electrodes. The architecture is described as compatible with microchip and flexible printed circuit board integration in adhesive patch formats.

Claims Coverage

The relevant independent claim is one system claim with multiple main structural and functional requirements, including four modules and a specific passive flow regulation implementation comprising a surface property barrier and a capillary pump positioned between the sensing module and the waste module.

Across the independent claim, the core claim coverage centers on a wearable system architecture that integrates biofluid collection, a sensing module that determines chemical and/or physical properties, passive flow regulation using a surface property barrier plus a downstream capillary pump, and a waste module for disposal after analysis.

Stated Advantages

Documented Applications

No documented applications found