Hierarchical adaptive closed-loop fluid resuscitation and cardiovascular drug administration system
Inventors
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Assignees
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Autonomous HealthcareAutonomous Healthcare develops autonomous systems for critical care, applying advanced algorithms and modeling to automate and support processes such as mechanical ventilation and hemodynamic management in intensive care units. The company leverages expertise from aerospace engineering and artificial intelligence to provide continuous clinical vigilance, validated through rigorous research and regulatory milestones.
Autonomous Healthcare develops autonomous systems for critical care, applying advanced algorithms and modeling to automate and support processes such as mechanical ventilation and hemodynamic management in intensive care units. The company leverages expertise from aerospace engineering and artificial intelligence to provide continuous clinical vigilance, validated through rigorous research and regulatory milestones.
Publication Number
US-11707571-B2
Publication Date
2023-07-25
Expiration Date
Abstract
The present disclosure describes a closed-loop fluid resuscitation and/or cardiovascular drug administration system that uses continuous measurements and adaptive control architecture. The adaptive control architecture uses a function approximator to identify unknown dynamics and physiological parameters of a patient to compute appropriate infusion rates and to regulate the endpoint of resuscitation.
Core Innovation
The invention provides a hierarchical adaptive closed-loop and clinical decision support method for fluid and/or cardiovascular drug administration. The method receives at least one initial infusion rate via a user interface and receives hemodynamic measurements from a subject by a hierarchical control architecture system. The hierarchical control architecture system includes at least one lower-level controller and a higher-level logic controller in communication with one another.
The subject’s hemodynamic measurements are received by both the higher-level logic controller and the at least one lower-level controller. The at least one lower-level controller includes an internal dynamical system model that adapts to a dynamical system model of the subject. Parameters of the internal dynamical system model are initialized based at least in part on the at least one initial infusion rate so that the lower-level controller initially generates an infusion rate equal to the at least one initial infusion rate.
At set time intervals, the lower-level controller generates a new infusion rate based at least in part on the hemodynamic measurements and the parameters of the internal dynamical system model. The method further includes notifying the user and disengaging the at least one lower-level controller if at least one infusion therapy performance criterion is violated by dropping below or exceeding a set threshold, and administering the fluid and/or cardiovascular drug at the new infusion rate.
Claims Coverage
The relevant independent claim is a method claim that specifies an adaptive hierarchical control architecture with user-provided initial infusion rate input, sensor-based infusion-rate updates, and safety-driven disengagement/notification when infusion therapy performance criteria are violated. The claim includes five main inventive features.
Hierarchical control architecture for infusion therapy
Receiving from a sensor hemodynamic measurements of a subject by a hierarchical control architecture system comprising at least one lower-level controller and a higher-level logic controller; wherein the subject's hemodynamic measurements are received by the higher-level logic controller and the at least one lower-level controller; wherein the at least one lower-level controller and the higher-level logic controller are in communication with one another.
Adaptive internal dynamical system model in lower-level controller
The at least one lower-level controller has an internal dynamical system model that adapts to a dynamical system model of the subject.
Initialize internal model using initial infusion rate
Initializing parameters of the internal dynamical system model of the at least one lower-level controller based at least in part on the at least one initial infusion rate such that the lower-level controller generates an infusion rate equal to the at least one initial infusion rate.
Set-interval infusion-rate updates from hemodynamics
Generating a new infusion rate by the lower-level controller at set time intervals based at least in part on the hemodynamic measurements and the parameters of the internal dynamical system model of the at least one lower-level controller.
Notification and disengagement on performance-criterion violation
Notifying the user and disengaging the at least one lower-level controller if at least one infusion therapy performance criterion is violated by dropping below or exceeding a set threshold; and administering the fluid and/or cardiovascular drug at the new infusion rate to the subject.
Across the independent claim, the method is grounded in a hierarchical control architecture that uses an adaptive internal dynamical system model in a lower-level controller to update infusion rates from sensor hemodynamics at set intervals, while a higher-level logic controller supports receiving the hemodynamics and enforcing safety-related disengagement and user notification when defined infusion therapy performance criteria are violated.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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