System and method for obtaining a pupil response profile
Inventors
UYS, ASHLEY THURSTON • ENTHOVEN, STEFAN • DUGGAN, KIERAN EAMON • BARNES, KEA FRANCIS
Assignees
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Publication Number
US-11690509-B2
Publication Date
2023-07-04
Expiration Date
Abstract
A system and method are provided for obtaining a pupil response profile for a subject. The method include: obtaining scan data as frames of a pupil response over time prior to, during and after exposure to a flash of a light source; locating a candidate pupil to be measured from the scan data; image processing the scan data to obtain a set of pupil candidate measurements to generate a graph of pupil measurements against time; filtering the graph to produce a final set of pupil measurements forming a pupil response profile. The method may also include: measuring profile parameters from the pupil response profile; and using the profile parameters to determine aspects of the pupil response.
Core Innovation
A computer-implemented method obtains scan data as frames of a pupil response over time prior to, during and after exposure to a flash of a light source, wherein one or more of the frames include a reflection of a pupil locating light source of a given shape. A candidate pupil to be measured is located from the scan data including identifying a generally circular image including a reflection of the given shape.
The scan data is image processed to obtain a set of pupil measurements to generate a graph of pupil measurements against time. The pupil measurements are standardised by using a ratio of a measured pupil size and a measured distance between respective reflections of the given shape in the scan data of two eyes of a subject.
The graph is filtered to produce a final set of pupil measurements forming a pupil response profile. Profile parameters are measured from the pupil response profile, and the profile parameters are used to determine aspects of the pupil response.
Claims Coverage
The provided excerpt contains two independent claims, a method claim and a system claim. Both claims share a core inventive pipeline with five inventive features: flash-time scan data with a given-shape reflection, candidate pupil locating, standardised pupil measurements, filtering to form a pupil response profile, and profile parameters used to determine aspects of the pupil response.
Flash-time pupil response scan and reflection-based pupil candidate locating
Obtaining scan data as frames of a pupil response over time prior to, during and after exposure to a flash of a light source, wherein one or more of the frames include a reflection of a pupil locating light source of a given shape; locating a candidate pupil to be measured from the scan data including identifying a generally circular image including a reflection of the given shape.
Standardised time-graph of pupil measurements using a pupil-size and reflection-distance ratio
Image processing the scan data to obtain a set of pupil measurements to generate a graph of pupil measurements against time, including standardising the pupil measurements by using a ratio of a measured pupil size and a measured distance between respective reflections of the given shape in the scan data of two eyes of a subject.
Filtering to produce a pupil response profile and deriving profile parameters for determining aspects of the pupil response
Filtering the graph to produce a final set of pupil measurements forming a pupil response profile; measuring profile parameters from the pupil response profile; using the profile parameters to determine aspects of the pupil response.
System components for obtaining and processing pupil response profile from flash scans
A processing system comprising an input component for obtaining scan data as frames of a pupil response over time prior to, during and after exposure to a flash of a light source including a reflection of a pupil locating light source of a given shape; a pupil locating component for locating a candidate pupil from the scan data including identifying a generally circular image including a reflection of the given shape; an image processing component for image processing the scan data including standardising the pupil measurements by using a ratio of a measured pupil size and a measured distance between respective reflections of the given shape in the scan data of two eyes of a subject; a filtering component for filtering the graph to produce a final set of pupil measurements forming a pupil response profile; a profile parameter component for measuring profile parameters from the pupil response profile; and an output component for using the profile parameters to determine aspects of the pupil response.
Across both independent claims, the inventive concept is centered on obtaining scan frames around a flash where a given-shape pupil-locating reflection is present, locating a generally circular candidate pupil using that reflection, forming a time graph with standardised pupil measurements using a ratio of pupil size to reflection-distance across two eyes, filtering to produce a pupil response profile, and measuring profile parameters to determine aspects of the pupil response.
Stated Advantages
Documented Applications
Using the profile parameters to determine aspects of the pupil response for detecting disease/substance/nerve/vein-artery-capillary impairments.
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