Characterization of blood hemostasis and oxygen transport parameters
Inventors
Viola, Francesco • Walker, William F.
Assignees
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Publication Number
US-11680940-B2
Publication Date
2023-06-20
Expiration Date
Abstract
An integrated system for determining a hemostasis and oxygen transport parameter of a blood sample, such as blood, is disclosed. The system includes a measurement system, such as an ultrasonic sensor, configured to determine data characterizing the blood sample. For example, the data could be displacement of the blood sample in response to ultrasonic pulses. An integrated aspect of the system may be a common sensor, sample portion or data for fast and efficient determination of both parameters. The parameters can also be used to correct or improve measured parameters. For example, physiological adjustments may be applied to the hemostatic parameters using a HCT measurement. Also, physical adjustments may be applied, such as through calibration using a speed or attenuation of the sound pulse through or by the blood sample. These parameters may be displayed on a GUI to guide treatment.
Core Innovation
The invention provides a system for determining properties of a blood sample using a cartridge having one or more first transducers and one or more second transducers. The first transducers apply one or more first signals to a first portion of the blood sample and detect one or more first responses to generate data quantifying the one or more first responses. The second transducers apply one or more second signals to a second portion of the blood sample and detect one or more second responses to generate data quantifying the one or more second responses.
A processor and memory execute instructions to receive the data quantifying the first responses and the second responses. The processor determines at least one oxygen transport parameter of the blood sample using at least a portion of the data quantifying the one or more first responses, and determines at least one hemostasis parameter of the blood sample using at least a portion of the data quantifying the one or more first responses and the one or more second responses.
The hemostasis parameter is determined, in part, by adjusting the hemostasis parameter using the determined oxygen transport parameter. The integrated sonorheometry system derives hemostasis parameters from ultrasonic acoustic-radiation-force displacement measurements while simultaneously measuring oxygen-transport parameters using ultrasound characteristics such as speed of sound, attenuation, and backscatter.
The disclosure includes correcting hemostasis indices based on oxygen-transport metrics, and provides a cartridge or microfluidic architecture enabling parallel reagent wells with immobilized reagents, agonists, and antagonists to isolate intrinsic, extrinsic, and common pathways, together with GUI-based display for clinical guidance including transfusion options.
Claims Coverage
Independent claim clm-00001 covers a cartridge-based blood analysis system that determines oxygen transport parameters and hemostasis parameters from first and second acquisition channels, and further covers adjusting the hemostasis parameter using the determined oxygen transport parameter.
Cartridge with first and second acquisition channels for dual-signal response quantification
A system comprising one or more first transducers associated with a first acquisition channel of a cartridge and one or more second transducers associated with a second acquisition channel of the cartridge, where the first transducers apply one or more first signals to a first portion of the blood sample and detect one or more first responses to generate data quantifying the first responses, and where the second transducers apply one or more second signals to a second portion of the blood sample and detect one or more second responses to generate data quantifying the second responses.
Oxygen transport parameter and hemostasis parameter determination from channel data
A processor and a memory execute instructions to receive the data quantifying the one or more first responses and the one or more second responses, determine at least one oxygen transport parameter using at least a portion of the data quantifying the one or more first responses, and determine at least one hemostasis parameter using at least a portion of the data quantifying the one or more first responses and the one or more second responses.
Adjusting hemostasis parameter using oxygen transport parameter
The system wherein at least one hemostasis parameter is determined, in part, by adjusting the hemostasis parameter using the determined oxygen transport parameter.
Across the covered independent claim, the core structure is dual acquisition channels in a cartridge that quantify ultrasound responses, determine both oxygen transport and hemostasis parameters from the acquired data, and then adjust the hemostasis parameter based on the oxygen transport parameter.
Stated Advantages
Corrects hemostasis indices based on oxygen-transport metrics.
Enables determination of hemostasis parameters and oxygen-transport parameters while using the same overall ultrasonic/sonorheometry framework.
Supports GUI-based display for clinical guidance including transfusion options.
Provides reproducibility, with reported CV <6% for most parameters.
Documented Applications
Blood hemostasis analysis using integrated sonorheometry with ultrasonic acoustic-radiation-force displacement measurements and oxygen-transport parameter measurement via ultrasound characteristics.
Clinical guidance including transfusion selection, with transfusion options described as fresh frozen plasma, platelet concentrates, cryoprecipitate, antifibrinolytics, and packed RBCs.
Assessment of hemostasis effects using fibrin polymerization inhibition (GPRP), platelet aggregation inhibition (abciximab), and fibrinolysis activation (urokinase).
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