Vibrio parahaemolyticus bacteriophage Vib-PAP-7 and use of same for inhibiting vibrio parahaemolyticus bacteria proliferation
Inventors
Yoon, Seong Jun • JUN, Soo Youn • KWON, An Sung • Song, Hyun Min • Lee, Eun Ji • Kang, Sang Hyeon
Assignees
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Publication Number
US-11679138-B2
Publication Date
2023-06-20
Expiration Date
Abstract
The present invention relates to a Myoviridae bacteriophage Vib-PAP-7 (Accession number: KCTC 13247BP) isolated from nature, which has the ability to kill Vibrio parahaemolyticus and has the genome represented by SEQ ID NO: 1, and a method for preventing or treating a disease caused by Vibrio parahaemolyticus using a composition containing the Myoviridae bacteriophage Vib-PAP-7 as an active ingredient.
Core Innovation
The invention relates to a composition for blocking a Vibrio parahaemolyticus infection, inhibiting the development of diseases caused by a Vibrio parahaemolyticus infection, suppressing diseases caused by Vibrio parahaemolyticus, or alleviating the pathological condition of the diseases caused by Vibrio parahaemolyticus. The composition comprises maltodextrin and 1×10^4 to 1×10^15 plaque-forming units per gram (pfu/g) of proliferated and purified Myoviridae bacteriophage Vib-PAP-7 in a dried mixture.
Myoviridae bacteriophage Vib-PAP-7 has an ability to specifically kill Vibrio parahaemolyticus and has a genome represented by SEQ ID NO: 1. The invention identifies Vib-PAP-7 as deposited in the Korean Collection for Type Cultures (KCTC) under accession number KCTC 13247BP, thereby defining the phage used in the composition.
Claims Coverage
The provided content identifies one independent claim. It covers one inventive composition concept with two core features: a dried mixture of maltodextrin and a specified titer of Myoviridae bacteriophage Vib-PAP-7, and a defined phage identity by SEQ ID NO: 1 and KCTC 13247BP.
Dried mixture composition with maltodextrin and Vib-PAP-7 titer range per gram
A composition comprising maltodextrin and 1×10^4 pfu/g to 1×10^15 pfu/g of proliferated and purified Myoviridae bacteriophage Vib-PAP-7, wherein the maltodextrin and Myoviridae bacteriophage Vib-PAP-7 are in a dried mixture, for blocking a Vibrio parahaemolyticus infection, inhibiting the development of diseases caused by the infection, suppressing diseases caused by Vibrio parahaemolyticus, or alleviating the pathological condition of the diseases.
Specific Vibrio-parahaemolyticus-killing phage identity defined by SEQ ID NO: 1 and KCTC 13247BP
The composition uses Myoviridae bacteriophage Vib-PAP-7 having an ability to specifically kill Vibrio parahaemolyticus and a genome represented by SEQ ID NO: 1, deposited in the Korean Collection for Type Cultures (KCTC) under accession number KCTC 13247BP.
Across the independent claim, the inventive concept is a dried mixture of maltodextrin with a specified range of pfu/g of Myoviridae bacteriophage Vib-PAP-7 that specifically kills Vibrio parahaemolyticus, where the phage is defined by SEQ ID NO: 1 and KCTC 13247BP.
Stated Advantages
Blocks a Vibrio parahaemolyticus infection.
Inhibits the development of diseases caused by a Vibrio parahaemolyticus infection.
Suppresses diseases caused by Vibrio parahaemolyticus.
Alleviates the pathological condition of diseases caused by Vibrio parahaemolyticus.
Documented Applications
Use as a composition to prevent or treat Vibrio parahaemolyticus infection/disease.
Medicine bath agent (immersion agent).
Feed additive using maltodextrin/phage in a freeze-dried mixture.
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