Treatment planning for alpha particle radiotherapy
Inventors
Kelson, Itzhak • Arazi, Lior • Gat, Amnon • Heger, Guy
Assignees
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Publication Number
US-11666781-B2
Publication Date
2023-06-06
Expiration Date
Abstract
Apparatus for planning a diffusing alpha-emitter radiation therapy (DaRT) treatment session. The apparatus includes an output interface and a memory configured with a plurality of tables which provide an accumulated measure of radiation over a specific time period, due to one or more types of DaRT radiotherapy sources which emit daughter radionuclides from the source, for a plurality of different distances and angles relative to the DaRT radiotherapy source. In addition, a processor is configured to receive a description of a layout of a plurality of DaRT radiotherapy sources in a tumor, to calculate a radiation dose distribution in the tumor responsive to the layout, using the tables in the memory, and to output feedback for the treatment responsive to the radiation dose distribution, through the output interface.
Core Innovation
The disclosed invention concerns planning a diffusing alpha-emitter radiation therapy (DaRT) treatment session using the layout of DaRT radiotherapy sources in a tumor. An apparatus or processor uses tables that provide accumulated measures of radiation across specified time periods, distances, and angles to calculate a radiation dose distribution and provide feedback. The planning process also receives tumor tissue parameters to calculate radionuclide and dose distributions, set treatment-session parameters, and provide feedback to a human operator.
The framework incorporates time- and position-dependent radiation tables, selection according to treatment duration or tumor zone, and calculation of distributions for radon-220, lead-212, and bismuth-212. It also evaluates comparisons between dose models, finite-source models, and simplified line-source approximations under varying diffusion lengths and lead leakage assumptions. Because the background section is omitted, the underlying problem is not explicitly described in patent.
Claims Coverage
The claims identify three inventive features across three independent claims, covering an apparatus and methods for planning radiotherapy treatment sessions.
Table-based treatment planning apparatus
The apparatus stores tables providing accumulated measures of radiation over specific time periods, distances, and angles relative to DaRT radiotherapy sources, while a processor receives the source layout in a tumor, calculates a radiation dose distribution using the tables, and outputs feedback responsive to that distribution.
Table-based radiotherapy planning method
The method receives a layout of DaRT radiotherapy sources in a tumor, calculates a radiation dose distribution using tables of accumulated radiation measures for source types, time periods, distances, and angles, and outputs treatment-session feedback responsive to the distribution.
Radiotherapy planning using tumor tissue parameters and radiation-dose distributions
The method receives tumor tissue parameters and a layout of DaRT sources, calculates distributions of radon-220, lead-212, and bismuth-212, determines radiation-dose distributions resulting from alpha radiation and from electron and photon radiation, sets treatment-session parameters, and outputs feedback to a human operator responsive to the determined distributions.
Together, the inventive features cover a table-based planning apparatus, a table-based planning method, and a method that uses tumor tissue parameters and calculated radionuclide and radiation-dose distributions to set treatment-session parameters and provide feedback.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Planning a diffusing alpha-emitter radiation therapy (DaRT) treatment session for a tumor requiring radiotherapy, including calculating radiation dose distributions, setting session parameters, and providing feedback.
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