Delivery systems for control of bleeding in transurethral prostatectomy
Inventors
McCarthy, Simon J. • JONES, Mattie R. • Xie, Hua
Assignees
Oregon Health and Science University • Tricol Biomedical Inc
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Publication Number
US-11660236-B2
Publication Date
2023-05-30
Expiration Date
Abstract
The present disclosure relates to a gastrointestinal delivery device of a chitosan dressing, where the delivery device is capable of stop bleeding, in particular in connection with TURP procedures. The delivery device may be used in all gastrointestinal bleeding applications and can be used with a biocompatible, foldable, thin profile, chitosan dressing. Various aspects of the device and its uses are provided herein.
Core Innovation
The disclosure provides a method for applying an endoluminal hemostatic dressing comprising catechol modified chitosan by mounting the dressing onto a balloon of a balloon catheter in a compact condition. The dressing is inserted through a urethra into a bladder of a patient, and the balloon is inflated to expand the dressing from the compact condition to an open condition so that the dressing is pressed against internal tissues of the patient.
The dressing is configured to adhere to wet internal tissues of the patient rapidly, and the method includes adhering the dressing to wet internal tissues to achieve rapid adherence and hemostasis. After pressing the dressing against the internal tissues, the balloon is deflated and the balloon catheter is removed from the bladder through the urethra while leaving the dressing in place against the internal tissues.
The pressing is specified as between 3 and 120 minutes and is associated with stopping bleeding at the internal tissues. The catechol modified chitosan chemistry is described as enabling rapid wet-tissue adhesion and bleeding control while maintaining dissolution behavior in bladder fluids until the dressing is no longer present.
Claims Coverage
The disclosure includes one independent claim directed to a method of delivering and using a catechol modified chitosan endoluminal dressing via a balloon catheter to stop bleeding, with inventive features spanning catheter-mounted compact-to-open delivery, rapid adhesion to wet internal tissues, defined balloon pressing time, and bleeding cessation with post-removal dressing retention.
Balloon catheter mounted catechol modified chitosan dressing in compact condition
An endoluminal dressing comprising catechol modified chitosan is mounted onto a balloon of a balloon catheter, the dressing mounted onto the balloon in a compact condition.
Transurethral delivery into bladder via balloon catheter
The dressing in the compact condition is inserted and the balloon of the balloon catheter is inserted through a urethra of a patient into a bladder of the patient.
Inflation to expand and press dressing against internal tissues
The balloon is inflated to expand the dressing from the compact condition to an open condition and to press the dressing against internal tissues of the patient.
Rapid adherence to wet internal tissues
The dressing adheres to wet internal tissues of the patient, wherein the adherence of the dressing to wet internal tissues of the patient is achieved rapidly.
Pressing time and bleeding stopping with dressing retention
The balloon is deflated and removed from the bladder through the urethra while leaving the dressing in place against the internal tissues, wherein inflating the balloon to press the dressing against internal tissues includes pressing the dressing against the internal tissues for between 3 and 120 minutes, and wherein inflating the balloon to press the dressing against internal tissues and leaving the dressing in place against the internal tissues stops bleeding at the internal tissues.
Across the inventive features, the claim coverage centers on delivering a catechol modified chitosan endoluminal dressing mounted on a balloon catheter through the urethra into the bladder, expanding and pressing it against wet internal tissues to achieve rapid adherence, and using a specified pressing duration to stop bleeding while retaining the dressing after balloon catheter removal.
Stated Advantages
Stops bleeding at internal tissues.
Rapid adherence of the dressing to wet internal tissues.
Allows removal of the balloon catheter while leaving the dressing in place against the internal tissues.
Documented Applications
No documented applications found
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