Diagnostics systems and methods
Inventors
Galen, Peter • Sayler, David John • Hoyt, Joshua King • Grupp, Daniel E. • Grimberg, Brian T. • GURKAN, UMUT ATAKAN
Assignees
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Publication Number
US-11656220-B2
Publication Date
2023-05-23
Expiration Date
Abstract
A point-of-care diagnostic system that includes a cartridge and a reader. The cartridge can contain a patient sample, such as a blood sample. The cartridge is inserted into the reader and the patient sample is analyzed. The reader contains various analysis systems, such as a magneto-optical system that measures a light transmission differential through the patient sample in varying magnetic fields. The reader can process data from the various patient sample analysis to provide interpretative results indicative of a disease, infection and/or condition of the patient.
Core Innovation
A point-of-care diagnostic system includes a reader and a disease-specific cartridge configured to analyze a patient biologic sample by using magneto-optical detection. The system measures light transmission while exposing the sample to varying magnetic field states and generates a differential light transmission characteristic based on transmitted light under the different magnetic field exposures.
The differential light transmission characteristic is used to detect biomarkers in the patient sample and to interpret disease or infection status. The document describes identifying a presence of a compound based on the characteristic and calculating a compound characteristic based on the presence of the compound or a byproduct of the compound and the differential light transmission characteristic.
The cartridge and reader integration supports automatic sample handling and diagnostic processing, including barrier actuation to release dilutant for mixing with the patient sample. The approach includes receiving multiple first light transmittance data under a first magnetic field and multiple second light transmittance data under a second magnetic field or when the sample is no longer exposed to the first magnetic field, then determining the differential light transmission characteristic from the multiple first and multiple second data.
Claims Coverage
The document provides two independent method claims. Each independent claim centers on automatic mixing of dilutant with a patient sample, magneto-optical measurement of multiple light transmittance datasets under different magnetic-field exposures, determining a differential light transmission characteristic, detecting presence of a compound or byproduct, calculating a compound characteristic, and generating an instruction to output the result.
Automatic release of dilutant for mixing with patient sample
Causing a barrier that separates a sample chamber from a dilutant chamber of a patient sample container to be actuated to automatically release dilutant stored in the dilutant chamber to be mixed with a patient sample stored in the sample chamber.
Differential light transmission characteristic under first and second magnetic-field exposures
After the dilutant is mixed with the patient sample in the sample chamber, receiving multiple first light transmittance data when the patient sample is exposed to a first magnetic field; receiving multiple second light transmittance data when the patient sample is exposed to a second magnetic field or is no longer exposed to the first magnetic field; determining a differential light transmission characteristic based on the multiple first and multiple second light transmittance data.
Compound detection and compound characteristic calculation from differential light transmission
Identifying presence of a compound or a byproduct of the compound in the patient sample based on a characteristic of the differential light transmission characteristic; calculating a compound characteristic based on the presence of the compound or the byproduct and the differential light transmission characteristic; generating an instruction to output the compound characteristic.
Alternating sequence of first and second data signals for differential characteristic
Receiving multiple first data signals representing light transmittance data generated when light is transmitted through a patient sample exposed to a first magnetic field; receiving multiple second data signals in an alternating sequence with the multiple first data signals, the multiple second data signals representing light transmittance data generated when the patient sample is exposed to a second magnetic field or is no longer exposed to the first magnetic field; determining a differential light transmission characteristic based on a portion of the multiple first data signals and a portion of the multiple second data signals.
Across both independent claims, the core claimed approach is automatic dilutant mixing followed by magneto-optical detection using multiple light transmittance datasets collected under first and second magnetic field conditions. The method determines a differential light transmission characteristic, uses it to identify presence of a compound or byproduct, calculates a compound characteristic, and generates an instruction to output the result.
Stated Advantages
Documented Applications
No documented applications found
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