Attachment device for single use containers
Inventors
Rudolph, Eric • Silverberg, Pete • Kofsky, Candice • Kubera, Paul • Reiss, Barry
Assignees
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Publication Number
US-11649426-B2
Publication Date
2023-05-16
Expiration Date
Abstract
This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals, using Disposable Containers (DCs).
Core Innovation
The claim describes a method for carrying out a reaction using a single-use container with a detachable attachment device. The device includes a first attachment mechanism within the container internal volume and a second attachment mechanism on the exterior, with both mechanisms attached to one another. The internal mechanism features a coupling groove for reversibly attaching a device such as an impeller assembly, while the external mechanism provides a reversible lifting point.
Drawings depict an agitator shaft with an impeller reversibly coupled inside the container, container-lifting arrangements, and container film panels with fasteners. Additional mechanical details include a spring-containing assembly, a circular flanged component, and a pocket for a lip seal. The coupling device is reported in connection with apparatus handling, single-use container assembly, transport, container deployment configurations, bag integrity testing procedures, and manufacturing of a chemical or biological product.
Claims Coverage
The claim coverage identifies one independent claim with four inventive features concerning a reaction method using a single-use container and coupled attachment mechanisms.
Reaction method using a single-use container
A method for carrying out a reaction using a single-use container comprising an internal volume and a detachable attachment device.
Coupled internal and external attachment mechanisms
The detachable attachment device comprises a first attachment mechanism within the internal volume and a second attachment mechanism on the exterior of the container, wherein the first and second attachment mechanisms are attached to one another.
Internal coupling groove for reversible device attachment
The first attachment mechanism comprises a coupling groove for reversibly attaching a device within the internal volume of the container thereto.
External reversible lifting point
The second attachment mechanism provides a lift point for reversibly attaching a lifting mechanism to the sterile single-use container.
The independent claim covers a reaction method utilizing a single-use container with coupled internal and external mechanisms: an internal coupling groove for reversibly attaching a device and an external lift point for reversibly attaching a lifting mechanism.
Stated Advantages
The bag integrity test is stated to be more sensitive than current integrity tests and can be performed during installation.
Documented Applications
Carrying out a reaction using a single-use container.
Manufacturing a chemical or biological product.
Single-use container assembly, deployment, and transport.
Performing a bag integrity test.
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