Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-11648180-B2
Publication Date
2023-05-16
Expiration Date
Abstract
A cartridge for use with a beneficial agent delivery device having a fillable reservoir. The cartridge includes a reconstitution, unit dose package having first and second compartments, and a fitment. The first compartment contains at least a first constituent of the beneficial agent. The second compartment contains at least a second constituent of the beneficial agent. The fitment is disposed on the package for interfacing the package to the fillable reservoir.
Core Innovation
The invention relates to an aseptic mixing/reconstitution cartridge or reconstitution unit dose package for beneficial-agent constituents. The package includes a first wall and a second wall that define sealed compartments for containing different constituents, with the compartment cavity adapted to maintain a preformed shape before the substance is introduced and after the substance is sealed in the compartment.
The package further includes peelable layers with peelable layer cavities that are preformed in accommodating shapes. The peelable layer cavity is adapted to accommodate a portion of the compartment cavity, and the peelable layer is arranged to overlay the second wall region defining the compartment. The described embodiments also support barrier management for moisture, oxygen, and light protection, with selective peeling for exposing areas for visual inspection and access to the compartment region.
A controlled activation sequence is achieved using frangible or peelable seals that rupture in a controlled sequence under compression, enabling mixing and transfer of constituents. The package is coupled to a dispenser via a fitment or coupler using a fluid-tight interface so that aseptic zones are maintained until activation, and optional static mixing at the interface or in passageways enhances mixing homogeneity.
Claims Coverage
The provided materials include two independent claims. The claims focus on the structural relationship between a first wall, a second wall that defines at least one compartment, and a peelable layer having a preformed or formed cavity that interacts with the compartment region.
Preformed sealed compartment cavity with matching peelable-layer cavity
A package including a first wall and a second wall defining at least a first compartment cavity sealed against the first wall, where the compartment cavity is adapted to maintain a preformed shape prior to introducing the substance and after the substance is sealed; and a peelable layer with a peelable layer cavity preformed in an accommodating shape substantially similar to the preformed compartment cavity, the peelable layer cavity adapted to accommodate a portion of the compartment cavity.
Transparent peelable layer with formed cavity overlaying compartment region
A package including a first wall and a second wall sealed against the first wall to define at least a first compartment to contain a substance; and a peelable layer including a cavity formed to accommodate the first compartment when arranged in contact with the second wall such that the cavity comprises a formed region that overlays the second wall defining the first compartment, wherein the peelable layer is transparent.
Across the independent claims, the inventive concept is a multi-wall sealed compartment package with a peelable layer whose cavity structure, preformed or formed, is sized and shaped to accommodate and overlay the compartment-defining region. The materials also mention barrier-performance relationships, frangible seal positioning, detachability to expose the compartment wall, adhesion-strength differences at interfaces, and a desiccant in the peelable layer.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
Interested in licensing this patent?