Triptan microporation delivery system
Inventors
Adachi, Hirotoshi • Horie, Shohei • Hanatani, Akinori • Nishimura, Masato • Yamada, Yuki • Hua, Joe
Assignees
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Publication Number
US-11638809-B2
Publication Date
2023-05-02
Expiration Date
Abstract
A transdermal delivery system for delivery of a triptan into a tissue membrane of a subject. The system includes a transdermal microporation apparatus for heating a skin surface and a triptan drug delivery patch. The drug delivery patch comprises a top layer comprising an adhesive, a middle layer comprising the triptan, and a bottom layer. A method for treating a subject comprises identifying a subject having a migraine, using the transdermal microporation apparatus to open a plurality of micropores in the skin of the subject, and applying the triptan drug delivery patch to the subject's skin over the micropores for a period of time effective to deliver the triptan through the micropores in an amount effective to treat the subject's migraine.
Core Innovation
The invention provides a transdermal triptan delivery patch constructed as a layered triptan drug delivery patch with a top layer comprising an adhesive, a middle layer comprising a triptan, a skin irritation reducer, an anti-microbial agent, and a stabilizer, and a bottom layer comprising a release liner. The patch is configured to deliver a triptan drug to a subject in need thereof through skin micropores.
The invention further provides a transdermal microporation apparatus for heating a skin surface, combined with the layered triptan drug delivery patch, to support transdermal drug delivery via micropores. The described approach is characterized as opening a plurality of micropores in the skin and delivering a therapeutically effective amount of the triptan through the plurality of micropores over a selected period of time.
The middle layer composition includes a skin irritation reducer, an anti-microbial agent, and a stabilizer to address skin irritation and formulation stability. The document context describes triptan selections such as zolmitriptan, sumatriptan, and rizatriptan, and describes formulation components that function as stabilizers such as saccharides.
The described embodiments and study context report comparative pharmacokinetics, including AUC, Cmax, and Tmax, and skin irritation outcomes versus other delivery routes. The invention context characterizes delivery performance as improved bioavailability with acceptable irritation under optimized microporation parameters.
Claims Coverage
The document includes three independent claims that collectively cover a layered triptan patch, a migraine treatment method using skin micropores and the patch, and a transdermal drug delivery patch system combining a heating-based transdermal microporation apparatus with the layered triptan patch. The inventive coverage centers on the layered patch construction and delivery via thermally opened micropores.
Layered triptan patch with adhesive top, medicated middle, and release liner bottom
A patch for delivering a triptan drug to a subject in need thereof, comprising a top layer comprising an adhesive; a middle layer comprising a triptan, a skin irritation reducer, an anti-microbial agent, and a stabilizer; and a bottom layer wherein the bottom layer comprises a release liner.
Micropore-based migraine treatment using the layered triptan patch
A method of treating a subject in need thereof, comprising identifying a subject having a migraine; opening a plurality of micropores in the skin of the subject; applying a patch to the subject's skin over the micropore for a period of time, wherein the patch comprises a top layer comprising an adhesive; a middle layer comprising a triptan, a skin irritation reducer, an anti-microbial agent, and a stabilizer; and a bottom layer, wherein the bottom layer comprises a release liner, wherein the period of time is selected to deliver a therapeutically effective amount of the triptan through the plurality of micropores.
Heating-based transdermal microporation apparatus with layered triptan patch
A transdermal drug delivery patch system for delivering a drug, comprising a transdermal microporation apparatus for heating a skin surface; and a triptan drug delivery patch, wherein the drug delivery patch comprises a top layer comprising an adhesive, a middle layer comprising a triptan, a skin irritation reducer, an anti-microbial agent, and a stabilizer, and a bottom layer wherein the bottom layer comprises a release liner.
Across the independent claims, the core claim coverage is a layered triptan patch used for transdermal delivery through a plurality of micropores. The method claim uses the micropore opening and selected application time to deliver a therapeutically effective amount for migraine, and the system claim ties this patch to a transdermal microporation apparatus for heating a skin surface.
Stated Advantages
Improved bioavailability with acceptable irritation under optimized microporation conditions.
Documented Applications
Treating a subject having a migraine by opening a plurality of micropores in the skin and delivering a therapeutically effective amount of a triptan through the plurality of micropores using the layered patch.
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