Compositions and methods for adhesion to surfaces
Inventors
Hess, Brian J. • Kay, George W.
Assignees
Publication Number
US-11638777-B2
Publication Date
2023-05-02
Expiration Date
2036-05-27
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Abstract
The present disclosure features adhesive compositions and methods of use thereof related to the medical, veterinary, and dental fields.
Core Innovation
The invention relates to adhesive compositions and methods for their use, particularly in medical, veterinary, and dental fields. These adhesive compositions are formulated with a multivalent metal salt and a compound of Formula (I), such as phosphoserine, in an aqueous medium. The composition possesses adhesive properties that allow it to conform to surfaces, lute, and subsequently become a solid that can be applied to bone or device surfaces. The applied shape of the composition can be modified through flowing, molding, or plastic deformation before it hardens and becomes rigid.
A key innovation is that the composition may exhibit biological resorption characteristics, enabling it to be replaced by natural bone over time while maintaining the original applied volume—a property termed volume or space maintenance. The adhesive can be layered or applied in segments to fill voids, build desired structures, or adhere structures to surfaces. The formulation can be adjusted to modify aspects such as setting time, adhesive strength, porosity, mechanical properties, and interactions with both biological and non-biological materials.
The problem addressed by this invention is the limitation of current hardware-based bone fixation methods, which rely on mechanical features and bone quality rather than adhesion, often resulting in compromised outcomes when bone volume or density is insufficient due to anatomical, traumatic, or disease-related factors. The disclosed adhesive compositions offer a solution by providing direct adhesive fixation to bone or calcified tissues, enabling applications where mechanical devices are inadequate or where improved biological integration and sealing are needed.
Claims Coverage
The independent claim in the patent defines one main inventive feature relating to the method of joining bones, bone fragments, or bone segments using an injectable adhesive composition.
Joining bones with injectable adhesive composition
The method involves injecting an adhesive composition in a fluid state onto or into bones, bone fragments, or bone segments to be joined. - The adhesive composition comprises: - An organic phosphate compound (including phosphoserine or a compound of Formula (I) or a salt thereof) - A multivalent metal salt selected from tetracalcium phosphate or tricalcium phosphate - An aqueous medium, present at about 10% to about 35% of the composition to achieve a viscosity between 100 cP and 10,000 cP when in the fluid state - The multivalent metal salt is provided as a powder with a mean particle size between 0.005 mm and 0.150 mm - The method enables joining of two or more bones, bone fragments, or bone segments
The claims protect methods for joining bones by injecting a specific adhesive composition containing an organic phosphate compound, a multivalent metal salt powder with specified particle size, and an aqueous medium in defined proportions to achieve desired viscosity for fluid application and subsequent solidification.
Stated Advantages
The adhesive composition exhibits strong adhesive properties, enabling direct fixation to bone and other surfaces where traditional mechanical fixation may be compromised.
The composition allows for conformable application, flowing, molding, or shaping prior to hardening, which enables precise placement and adaptation to complex anatomical sites.
The adhesive can be biologically resorbed and replaced by natural bone over time, maintaining the original applied volume and supporting bone regeneration.
The adhesive composition can be engineered to harden or cure within about 30 minutes, facilitating efficient clinical use.
The composition forms a strong, durable, and stable barrier that prevents migration from the application site and seals against microbial and fibrous tissue ingress.
The method and composition enable primary stability and fixation for implants, devices, grafts, or bone segments without reliance solely on existing bone density or volume.
Documented Applications
Adhesively joining two or more bones, bone fragments, or bone segments in medical, dental, and veterinary procedures.
Increasing bone volume by applying the adhesive composition to extraction sockets, flat, or convex bone surfaces.
Filling bone voids resulting from removal of cysts, granulomas, abscesses, trauma, or disease processes.
Repairing bone defects, including those present at the root of a tooth or caused by congenital conditions, trauma, or surgical interventions.
Repairing defects or restoring load-bearing function in teeth, including repairing defects in contact with dental pulp.
Attaching dental devices, posts, crowns, or prosthetic devices to teeth, roots, implants, or retaining devices.
Sealing gaps between devices (implants, prostheses) and retaining devices (such as implants or stump implants) in dentistry and limb prosthesis.
Installing bone implants or devices by applying the adhesive composition to bone sites or device surfaces.
Closing wounds or sealing sites from incursion of fluids or microbes, including urgent trauma settings, routine surgeries, and as temporary or definitive dressings.
Controlling excessive bleeding from bone injuries, fractures, or surgical sites by applying the adhesive at the site or onto adjunct solid materials.
Restoring bone deformities, such as cleft palate, or restoring load-bearing capacity to bones sectioned for orthognathic or reconstructive procedures.
Additively reshaping, molding, or contouring bone surfaces in cosmetic or reconstructive procedures.
Treating subjects suffering from diseases affecting bone or calcified tissue, including osteoporosis, cancers, metabolic, developmental, or genetic diseases.
Repairing bone defects from trauma and preparing and harvesting bone grafts or composites of bone and the hardened adhesive composition.
Adhesively repairing defects and fractures, and joining segments in non-human vertebrate animals or non-vertebrate animal structures such as corals.
Repairing, bridging, or sealing gaps between articulating bone surfaces or for spinal fusion procedures, with or without supportive implant devices.
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