Tissue substitute multilayer matrix and uses thereof
Inventors
NSEIR MANASSA, Nora • BAHAR, Amir
Assignees
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Publication Number
US-11638774-B2
Publication Date
2023-05-02
Expiration Date
Abstract
Compositions-of-matter comprising a matrix made of one or more, preferably two or more elastic layers and one or more viscoelastic layer are disclosed. The compositions-of-matter are characterized by high water-impermeability and optionally by self-recovery. Processes of preparing the compositions-of-matter and uses thereof as tissue substitutes or for repairing damaged tissues are also disclosed.
Core Innovation
The invention provides a multi-layer matrix for tissue substitute. The matrix includes at least one layer of a viscoelastic polymeric material interposed between two or more layers of an elastic polymeric material. Each elastic polymeric material layer is in a form of a porous layer of polymeric fibers.
The viscoelastic polymeric material is characterized by at least one of a glass transition temperature below 0°C and a melting point at a temperature below 45°C. The polymeric fibers comprise poly(lactic acid-co-ε-caprolactone), and the viscoelastic polymeric material comprises poly(lactic acid-co-ε-caprolactone).
The described multi-layer tissue-substitute matrix is suturable/staple puncture compatible and is described as optionally having self-recovery after punctures. The matrix is characterized by high water-impermeability, including reduced leakage around suture holes, while providing balanced mechanical properties for suturing and stapling. The document emphasizes performance such as water-permeability less than 1 mL/hr/cm2 at 40 mmHg and leakage reduction even around suture punctures.
Claims Coverage
The independent claim defines a composition-of-matter for a multi-layer matrix. Its inventive features include a viscoelastic polymeric material layer interposed between porous elastic polymeric fiber layers, both using poly(lactic acid-co-ε-caprolactone), and defined thermal and material-form characteristics that further support suturing/stapling puncture performance.
Interposed viscoelastic layer between porous elastic fiber layers
A multi-layer matrix comprising at least one layer of a viscoelastic polymeric material interposed between two or more layers of an elastic polymeric material, wherein each elastic polymeric material layer is in a form of a porous layer of polymeric fibers.
Poly(lactic acid-co-ε-caprolactone) elastic fibers and viscoelastic material
The polymeric fibers comprise poly(lactic acid-co-ε-caprolactone) and the viscoelastic polymeric material comprises poly(lactic acid-co-ε-caprolactone.
Thermal-characterized viscoelastic polymeric material
The viscoelastic polymeric material is characterized by at least one of a glass transition temperature below 0°C and a melting point at a temperature below 45°C.
Overall, the claim coverage centers on a multi-layer matrix where a viscoelastic poly(lactic acid-co-ε-caprolactone) material layer is interposed between two or more porous elastic poly(lactic acid-co-ε-caprolactone) fiber layers, with the viscoelastic layer meeting defined thermal constraints.
Stated Advantages
High water-impermeability, including reduced leakage around suture holes.
Suturing/stapling puncture performance with reduced leakage even around puncture sites.
Balanced mechanical properties for suturing and stapling.
Optionally self-recovery after suturing or staple punctures.
Documented Applications
Dural substitute to prevent cerebrospinal fluid (CSF) leakage.
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