Applicator for water-soluble sheet-shaped preparation
Inventors
Quan, Ying-shu • Li, Ying-zhe • Higuchi, Kiyotsune • Tanaka, Hiroshi • Kamiyama, Fumio
Assignees
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Publication Number
US-11633580-B2
Publication Date
2023-04-25
Expiration Date
Abstract
A nozzle having at least one hole on an end portion having a plane with a size capable of holding a sheet-like water-soluble preparation. The nozzle also has concave-convex portions on a portion of the plane excluding the hole. An applicator for a sheet-like water-soluble preparation, which is composed of a liquid container and the nozzle.
Core Innovation
An applicator nozzle is provided for applying a sheet-like water-soluble preparation to skin. The applicator includes a liquid container and a nozzle attached to an opening of the liquid container, where the nozzle has an end portion with a plane sized to hold the sheet-like water-soluble preparation and at least one hole on the plane.
The nozzle has concave-convex portions on a portion of the plane excluding the hole. A liquid is supplied to the back side of the sheet-like water-soluble preparation by pressing the liquid container, where the liquid reaches the back side through the hole.
The nozzle material is a soft polymer material selected from a group consisting of a soft polyolefin resin, a polyurethane resin and a silicone resin, and the soft polymer material has a Young’s modulus of 500 Pa to 5 MPa. The concave-convex portions can define grooves extending from the hole to a peripheral edge of the end portion, and a peripheral edge can be surrounded by a convex portion that is higher than the concave-convex portions.
Claims Coverage
Independent claim 1 covers an applicator with a liquid container and a soft-polymer nozzle that holds a sheet-like water-soluble preparation on a plane end portion. It includes at least one hole and concave-convex portions excluding the hole, and liquid is supplied to the back side by pressing the liquid container. Across the claims, six inventive features are identified.
Hole on plane end portion holding sheet-like preparation with concave-convex portions excluding hole
The nozzle has at least one hole on an end portion having a plane capable of holding the sheet-like water-soluble preparation, and has concave-convex portions on a portion of the plane excluding the hole.
Soft polymer nozzle material with specified Young’s modulus
The nozzle material is a soft polymer material selected from a group consisting of a soft polyolefin resin, a polyurethane resin and a silicone resin, with a Young's modulus of 500 Pa to 5 MPa.
Liquid supplied to back side of sheet-like preparation by pressing container
The sheet-like water-soluble preparation is held on the end portion of the nozzle so as to be applied to the skin, and liquid is supplied to a back side of the sheet-like water-soluble preparation by pressing the liquid container.
Concave-convex portions depth constraint
The concave-convex portions have a depth of 0.1 to 3.0 mm.
Grooves extending from hole to peripheral edge formed by concave-convex portions
The concave-convex portions create grooves extending from the hole to the peripheral edge of the end portion.
Peripheral convex portion higher than concave-convex portions
The end portion has a peripheral edge surrounded by a convex portion that is higher than the concave-convex portions.
The claims focus on a soft polymer nozzle that holds a sheet-like water-soluble preparation on a plane end portion while a hole supplies liquid to the back side during application. The inventive coverage further specifies the nozzle’s soft-material Young’s modulus and concave-convex geometry, including depth, grooves extending from the hole to the periphery, and a peripheral convex portion higher than the concave-convex portions.
Stated Advantages
Rapid dissolution is reported in Example 1.
Improved delivery is reported versus a flat-bottom comparative nozzle and a tape-held comparative method.
Documented Applications
Volunteer forehead microneedle application is described in connection with microneedle patches and water-soluble gel sheets and associated products.
Application to skin is described for the sheet-like water-soluble preparation.
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