Methods for compositions for reducing or eliminating symptoms of withdrawal from drugs and alcohol

Inventors

Muran, Peter J.

Assignees

Longevity Healthcare Center

Abstract

Methods and compositions of reducing or eliminating the symptoms of withdrawal from drug or alcohol in drug or alcohol-dependent persons, while restoring the patient to nutritional health. The methods including parenteral administration of solutions containing high doses of ascorbic acid; while the compositions of the invention comprise at least about 20% (w), or at least about 25% (w), or at least about 30% (w), or at least about 35% (w), or at least about 38% (w) of ascorbic acid and a local anesthetic.

Core Innovation

The invention relates to a method for attenuating symptoms of withdrawal to drugs or alcohol in a patient by rapidly restoring nutritional health and providing an altered biochemical environment during withdrawal. It uses sequential parenteral administration that includes high-dose ascorbic acid and an alkalinizing agent, with the stated rationale of avoiding oral diarrhea and addressing oxidative stress/free radicals (ROS).

The method administers a solution containing 10 g or more of ascorbic acid at a concentration of 0.2 g/ml or greater together with an alkalinizing agent as part of a withdrawal-attenuation protocol. In described embodiments, the protocol also includes additional parenteral nutritional/antioxidant supplements, including glutathione, and supplemental nutrients such as vitamin B complex components and minerals, as well as amino acids and methylation agents.

The documented disclosure describes detoxification timing of about 4–7 hours, and reports an example multi-step IV/IV push regimen involving sequential administration of an isotonic IV bag, a hypertonic ascorbic-acid IV push, and a glutathione push/drip with saline. The disclosure further includes pre-treatment screening and individualized oral supplement packets to support the withdrawal process.

Claims Coverage

The provided independent claims cover three related methods for attenuating symptoms of withdrawal to drugs or alcohol using parenteral administration of a hypertonic ascorbic-acid solution together with an alkalinizing agent, and in one case co-administration of substantially isotonic saline. Across the independent claims, the core inventive elements are the ascorbic-acid dosage/concentration thresholds and the presence of an alkalinizing agent, with additional dependent features refining quantities, delivery rate, and added components such as glutathione.

All three independent claims require parenteral administration of a hypertonic solution with defined high ascorbic-acid dosage and concentration thresholds, together with an alkalinizing agent to attenuate withdrawal symptoms. One independent claim additionally requires administering a dose of substantially isotonic saline.

Stated Advantages

Documented Applications