Vaporized medicants and methods of use
Inventors
Chong, Alexander ChinHak • Bartkowski, William P • Thompson, Marshall A
Assignees
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Publication Number
US-11622985-B2
Publication Date
2023-04-11
Expiration Date
Abstract
A method and formulation for delivering a motion sickness antidote in a vaporized state using low temperatures to vaporize the formulation. The formulation contains an inert non-reactive compound that lowers the heat of vaporization of the formulation, and the motion sickness antidote. The formulation may optionally contain glycerin, alcohol, and/or water. Examples of inert non-reactive compounds that can sufficiently lower the heat of vaporization of the formulation include propylene glycol, vegetable glycerin and polysorbate. The formulation can be vaporized using a hand-held low temperature vaporizer or atomizer.
Core Innovation
The invention relates to a method for delivering medicants through inhalation using vaporization of a medicant solution. The medicant solution includes an excipient comprising propylene glycol, vegetable glycerin, water, and alcohol, together with diphenhydramine as a medicant. The excipient is described as lowering heat or temperature of vaporization relative to the active alone, such that vaporizing the excipient provides an inhalable delivery of the medicant molecules.
The method further includes vaporizing the medicant solution at a temperature ranging from approximately 90 degrees C. to approximately 385 degrees C. to provide an effective serving of the medicant solution to a user for inhalation. The excipient components are provided in approximate percentage ranges, including propylene glycol present at approximately 1 percent to approximately 30 percent of the excipient and vegetable glycerin present at approximately 1 percent to approximately 30 percent of the excipient, with water and alcohol each present at approximately 0.01 percent to approximately 30 percent of the excipient.
The vaporized delivery is implemented with a compact handheld low-temperature vaporizer/atomizer concept. In some embodiments, the excipient includes polysorbates, including polysorbate 20/40/60/80, and polysorbate selection and composition are described as influencing vapor characteristics and lung penetration. The disclosure also describes vaporization temperature as low-temperature vaporization, including ranges generally around 90 degrees C. to about 120 degrees C., while allowing extension up to about 385 degrees C.
Claims Coverage
The independent claim is a single method claim that covers a vaporization-based inhalation delivery technique using a defined excipient mixture and diphenhydramine, with vaporization at a specified temperature range to provide an effective inhalable serving. The independent claim includes 2 main inventive elements: a medicant solution with specified excipient components and a vaporization temperature range to deliver an effective serving.
Inhalable medicant solution with specified excipient mixture and diphenhydramine
Acquiring a medicant solution suitable for vaporization, the medicant solution comprising an excipient comprising propylene glycol present at approximately 1 percent to approximately 30 percent of the excipient, vegetable glycerin present at approximately 1 percent to approximately 30 percent of the excipient, water present at approximately 0.01 percent to approximately 30 percent of the excipient, and alcohol present at approximately 0.01 percent to approximately 30 percent of the excipient, and diphenhydramine.
Vaporization at 90 degrees C. to 385 degrees C. to provide an effective serving
Vaporizing the medicant solution at a temperature ranging from approximately 90 degrees C. to approximately 385 degrees C. such that an effective serving of the medicant solution is provided to a user for inhalation.
Across the inventive features, the claim coverage centers on delivering diphenhydramine via inhalation by vaporizing a medicant solution that contains a defined excipient mixture of propylene glycol, vegetable glycerin, water, and alcohol in specified ranges, with vaporization performed at approximately 90 degrees C. to approximately 385 degrees C. to provide an effective inhalable serving.
Stated Advantages
Provides an effective serving of the medicant solution to a user for inhalation using low-temperature vaporization relative to the active alone.
Documented Applications
Delivery of medicants through inhalation, including diphenhydramine as a motion sickness antidote.
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