Method and device for enhancing memory consolidation
Inventors
Le Van Quyen, Michel • CHARPIER, Stéphane • MAHON, Séverine
Assignees
Centre National de la Recherche Scientifique CNRS • Assistance Publique Hopitaux de Paris APHP • Institut National de la Sante et de la Recherche Medicale INSERM • Sorbonne Universite • Institut du Cerveau et de La Moelle Epiniere ICM
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Publication Number
US-11612743-B2
Publication Date
2023-03-28
Expiration Date
Abstract
The present invention relates to methods and devices to consolidate memory and/or cognitive functions by monitoring brain rhythms and delivering a stimulus at an appropriate stage of sleep cycle.
Core Innovation
The invention provides a non-invasive method for monitoring a subject's brain activity and emitting stimuli according to the subject's brain activity. A brain activity signal is received and monitored, and the method detects an end of a stage I of a non-REM light sleep state by detection of a negative peak with an amplitude inferior to -75 μV and an onset of a stage II of the non-REM light sleep state. Based on the detected onset of stage II, the method emits a first stimulus.
After the first stimulus is emitted, the method emits a second stimulus, and then repeats emitting the first stimulus and the second stimulus until an end of a stage IV of the non-REM light sleep state is detected based on the brain activity signal. The method then restarts steps IV to VII when an onset of a further stage II of the non-REM light sleep state is detected based on the brain activity signal. The approach is thus a closed-loop stimulation sequence aligned to non-REM light sleep stage transitions.
A corresponding device is described for implementing the non-invasive method. The device includes a monitoring device measuring the subject's brain activity, a stimulation device providing a first stimulus and a second stimulus, and a programmable microcontroller board configured to receive and monitor the brain activity signal, detect the end of stage I and the onset of stage II using the negative peak criterion and stage II onset, and cause the stimulation device to emit and repeat the stimuli through stage IV until stage IV ends, then repeat the sequence upon further stage II onset.
Claims Coverage
The document includes two independent claims: one directed to a non-invasive method and one directed to a device. Each independent claim specifies a closed-loop sequence of stimulus emissions based on detecting non-REM light sleep stage transitions, including a negative-peak criterion for end of stage I and a stage II onset trigger, with a repeating first/second stimulus pattern until stage IV ends and restarting upon further stage II onsets.
Non-invasive monitoring and transition-triggered dual stimuli during non-REM stages
A non-invasive method receiving and monitoring a brain activity signal, detecting an end of a stage I of a non-REM light sleep state by detection of a negative peak with an amplitude inferior to -75 μV and an onset of stage II of the non-REM light sleep state, emitting a first stimulus at the detection of the onset of stage II, emitting a second stimulus, repeating emitting the first stimulus and the second stimulus until an end of a stage IV is detected, and restarting steps IV to VII when an onset of a further stage II is detected.
Programmable microcontroller device implementing negative-peak and stage-transition based stimulus sequence
A device comprising a monitoring device for measuring a brain activity signal, a stimulation device providing a first stimulus and a second stimulus, and a programmable microcontroller board configured to receive and monitor the brain activity signal; detect the end of a stage I by detection of a negative peak with an amplitude inferior to -75 μV and an onset of stage II; cause the stimulation device to emit the first stimulus at detection of stage II onset; cause the stimulation device to emit the second stimulus; cause repeating of the first and second stimulus emissions until an end of stage IV is detected; and repeat steps IV to VII when the onset of stage II is detected.
Across both independent claims, the core coverage centers on closed-loop detection of non-REM stage I end and stage II onset using a negative-peak amplitude criterion, followed by emission of first and second stimuli that repeat until stage IV ends and restart on subsequent stage II onsets.
Stated Advantages
Documented Applications
No documented applications found
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