System and method for dynamically calibrating and measuring analyte concentration in diabetes management monitors

Inventors

Edney, Paul • Zheng, Ling • Petisce, James

Assignees

Insulet Corp

Abstract

An optical analyte sensor and diabetes management system is provided. The sensor preferably includes a hydrogel matrix for receiving a sample containing an analyte at unknown concentration, a light emitter for emitting light at a stimulation frequency, a light receiver for receiving a fluorescence signal at a first isosbestic frequency, and at a second frequency, for measuring an intensity of the fluorescence signal and the first and second frequencies. A processor determines a concentration of the analyte based on the respective intensities.

Core Innovation

The invention is a diabetes management system that uses an optical analyte sensor comprising a matrix for receiving a sample containing an analyte at an unknown concentration and a marker configured to change between a first emission state and a second emission state in the presence of the analyte. The optical analyte sensor further includes a light emitter for emitting light at a stimulation frequency upon the sample and a light receiver configured to receive a fluorescence signal from the sample at each of the first emission state and the second emission state.

A processor and computer-readable storage medium are used so that the processor measures an intensity of the fluorescence signal associated with the emission states. The processor determines the concentration of the analyte by measuring fluorescence intensity at a first isosbestic frequency corresponding to the first emission state and at a second variable frequency corresponding to the second emission state as a function of detection passband configurations.

The processor compares the intensity of and determines fractional concentrations of the first emission state and the second emission state at each of the first isosbestic frequency and the second variable frequency to determine the concentration of the analyte. The system includes a transceiver for transmitting a signal indicative of the concentration of the analyte.

Claims Coverage

The independent claim covers a diabetes management system using an optical analyte sensor with a marker that switches emission states and a processor that performs isosbestic-and-variable-frequency fluorescence measurements using detection passband configurations to determine analyte concentration; the sensor also includes transmission of a signal indicative of the concentration. The claims include 3 inventive features.

Overall, the claim coverage centers on using a marker that changes between first and second emission states, measuring fluorescence intensity at an isosbestic frequency and a variable frequency as a function of detection passband configurations, and using state fractioning to determine analyte concentration, with transceiver transmission of the concentration-indicative signal.

Stated Advantages

Documented Applications