System and method for treating haemorrhagic fluid for autotransfusion
Inventors
Gadrat, Francis • Chollet, Stéphane • Picot, Sylvain • FOREST-VILLEGAS, PATRICIA
Assignees
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Publication Number
US-11607478-B2
Publication Date
2023-03-21
Expiration Date
Abstract
The invention relates to a system, and the associated method for using said system, for treating haemorrhagic fluid previously taken from a patient for the purpose of autotransfusion, comprising a unit for treating (100) haemorrhagic fluid, said treatment unit (100) comprising: a filtration device (110) for tangential filtration comprising a filtration membrane (113) arranged in a housing (114) so as to separate an intake chamber (111) from a discharge chamber (112), the intake chamber (111) and the discharge chamber (112) each having an inlet (111a; 112a) and an outlet (111b; 112b) for fluids;a treatment pouch (140) having an inlet (140a) and an outlet (140b) fluidically connected by a recirculation line (150) to the outlet (111b) and to the inlet (111a) of the intake chamber (111) of the filtration device (110), respectively, allowing haemorrhagic fluid to circulate in the recirculation line (150) in a direction going from the outlet (140b) of the treatment pouch (140) to the inlet (140a) of the treatment pouch (140) through the intake chamber (111) of the filtration device (110);a cleaning line (180) fluidically connected to the inlet (112a) of the discharge chamber (112) of the filtration device (110) to convey cleaning fluid into said discharge chamber (112); anda first flow regulation member (181) arranged to regulate the flow in the cleaning line (180) and a second flow regulation member (131) arranged to regulate the flow in a discharge line (130) fluidically connected to the outlet (112b) of the discharge chamber (112) of the filtration device (110), so as to be able to control the pressure of cleaning fluid in the discharge chamber (112).
Core Innovation
The invention relates to a treatment system for treating hemorrhagic fluid previously taken from a patient for the purpose of autotransfusion. The system includes a treatment unit having a filtration device with a filtration membrane for tangential filtration arranged in a housing to separate an intake chamber from a discharge chamber, each having an inlet and an outlet for fluids.
A treatment pouch having an inlet and an outlet is fluidically connected by a recirculation line to the outlet and to the inlet of the intake chamber of the filtration device, allowing hemorrhagic fluid to circulate in the recirculation line. The recirculation direction is from the outlet of the treatment pouch to the inlet of the treatment pouch through the intake chamber of the filtration device.
An intake line supplies the treatment unit with hemorrhagic fluid taken for filtration through the filtration membrane to remove from the hemorrhagic fluid a filtrate comprising undesired compounds for autotransfusion. The treatment unit further comprises a first flow regulation member arranged to regulate flow in the recirculation line at the outlet of the treatment pouch, and a dilution line intended to convey dilution fluid into the treatment unit connected to the recirculation line between the outlet of the treatment pouch and the inlet of the intake chamber of the filtration device.
In the described embodiments, a cleaning line is added into the discharge chamber together with flow-regulation members to control cleaning-fluid pressure and enable transmembrane counterflow cleaning by obstructing the discharge line. The system also provides optional dilution line functionality, sensors for monitoring, and a removable cartridge with a mistake-proofing template and support coupling.
Claims Coverage
The provided content identifies one independent claim defining a tangential filtration autotransfusion treatment system with a treatment pouch, recirculation line, intake and discharge chambers, a discharge line, flow regulation at the treatment pouch outlet, and a dilution line. Additional features are described in the input, but are not presented as independent claims.
Tangential filtration device with intake and discharge chambers
A filtration device comprising a filtration membrane for tangential filtration arranged in a housing so as to separate an intake chamber from a discharge chamber, the intake chamber and the discharge chamber each having an inlet and an outlet for fluids.
Treatment pouch with recirculation line through filtration intake chamber
A treatment pouch having an inlet and an outlet fluidically connected by a recirculation line to the outlet and to the inlet of the intake chamber of the filtration device, allowing hemorrhagic fluid to circulate in the recirculation line from the outlet of the treatment pouch to the inlet of the treatment pouch through the intake chamber of the filtration device.
Intake line for supplying hemorrhagic fluid and removing undesired compounds via filtrate
An intake line fluidically connected to the recirculation line between the outlet of the treatment pouch and the inlet of the intake chamber of the filtration device, making it possible to supply the treatment unit with hemorrhagic fluid taken for filtration through the filtration membrane to remove from the hemorrhagic fluid a filtrate comprising undesired compounds for autotransfusion.
Discharge line for filtrate from discharge chamber outlet
A discharge line fluidically connected to the outlet of the discharge chamber of the filtration device so as to discharge the filtrate having passed through the filtration membrane from the intake chamber.
Flow regulation at treatment pouch outlet in recirculation line
A first flow regulation member arranged to regulate the flow in the recirculation line at the outlet of the treatment pouch.
Dilution line connected between treatment pouch outlet and filtration intake inlet
A dilution line intended to convey dilution fluid into the treatment unit, the dilution line being fluidically connected to the recirculation line at a position between the outlet of the treatment pouch and the inlet of the intake chamber of the filtration device.
The independent claim defines a treatment unit using tangential filtration with separate intake and discharge chambers, a treatment pouch connected by a recirculation line through the filtration intake chamber, and an intake/discharge arrangement for removing undesired-compound filtrate. It further requires flow regulation at the treatment pouch outlet and a dilution line connected within the recirculation line between the pouch outlet and the filtration intake inlet.
Stated Advantages
Remove from the hemorrhagic fluid a filtrate comprising compounds undesired for autotransfusion.
Reduced hemolysis and free hemoglobin elimination.
Residual heparin reduced to <=0.5 IU/ml.
Improved platelet/RBC/WBC yield.
Treatment time <=10 min (<=5 min optimum).
Documented Applications
Treating hemorrhagic fluid previously taken from a patient for the purpose of autotransfusion.
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